X-linked Charcot-Marie-Tooth disease type 3 (CMTX3) is a rare inherited neurological disorder that affects the peripheral nerves. It is caused by mutations in the GJB1 gene, which is located on the X chromosome. Symptoms of CMTX3 include muscle weakness and wasting, foot deformities, and sensory loss in the feet and legs. The disorder is progressive, meaning that symptoms worsen over time.

The symptoms of X-linked Charcot-Marie-Tooth disease type 3 (CMTX3) can vary from person to person, but generally include:

- Muscle Weakness and wasting in the lower legs and feet
- High arches of the feet
- Hammertoes
- Loss of sensation in the feet and lower legs
- Difficulty walking
- Loss of balance
- Difficulty climbing stairs
- Difficulty running or jumping
- Pain in the feet and lower legs
- Curvature of the spine (scoliosis)
- Abnormal gait (walking pattern)
- Foot drop (inability to lift the front part of the foot)
- Weakness in the hands and arms

X-linked Charcot-Marie-Tooth disease type 3 is caused by mutations in the GJB1 gene, which is located on the X chromosome. This gene provides instructions for making a protein called connexin 32, which is involved in the formation of gap junctions. Gap junctions are channels that allow small molecules to pass between cells. Mutations in the GJB1 gene lead to the production of an abnormal connexin 32 protein, which disrupts the formation of gap junctions and affects the function of the peripheral nerves.

1. Physical therapy: Physical therapy can help to improve muscle strength, coordination, and balance. It can also help to reduce pain and improve mobility.

2. Assistive devices: Assistive devices such as braces, canes, and walkers can help to improve mobility and reduce the risk of falls.

3. Medications: Medications such as pain relievers, muscle relaxants, and anticonvulsants can help to reduce pain and improve muscle strength.

4. Surgery: Surgery may be recommended to correct foot deformities or to release tight tendons.

5. Gene therapy: Gene therapy is a new treatment option that is being studied for X-linked Charcot-Marie-Tooth disease type 3. It involves introducing a healthy gene into the body to replace the mutated gene that causes the disease.

1. Being male
2. Having a family history of X-linked Charcot-Marie-Tooth disease type 3
3. Having a mutation in the GJB1 gene
4. Being of Ashkenazi Jewish descent

At this time, there is no cure for X-linked Charcot-Marie-Tooth disease type 3. However, there are medications that can help manage the symptoms of the disease. These medications include anticonvulsants, muscle relaxants, and pain relievers. Physical therapy and occupational therapy can also help to improve muscle strength and coordination.