WT limb-blood syndrome is a rare genetic disorder caused by a mutation in the WT1 gene. It is characterized by a wide range of physical and developmental abnormalities, including limb malformations, blood disorders, and kidney and urinary tract abnormalities. It is also associated with intellectual disability and hearing loss.

The symptoms of WT limb-blood syndrome vary from person to person, but may include:

-Abnormalities of the hands and feet, including webbing of the fingers and toes, extra digits, and/or missing digits
-Abnormalities of the face, including a wide-set eyes, a flat nasal bridge, and/or a small lower jaw
-Abnormalities of the heart, including a hole in the heart, an abnormal heart rhythm, and/or an enlarged heart
-Abnormalities of the kidneys, including cysts, scarring, and/or an abnormal shape
-Abnormalities of the blood, including low platelet counts, low red blood cell counts, and/or low white blood cell counts
-Abnormalities of the bones, including short stature, curved spine, and/or abnormal bone

The exact cause of WT limb-blood syndrome is unknown. However, it is believed to be caused by a genetic mutation in the WT1 gene, which is responsible for the production of a protein called Wilms tumor 1. This protein is involved in the development of the kidneys, gonads, and other organs. Mutations in this gene can lead to the development of WT limb-blood syndrome.

The treatments for WT limb-blood syndrome vary depending on the severity of the condition and the individual patient. Generally, treatment focuses on managing the symptoms and preventing further complications. This may include physical therapy, occupational therapy, and orthopedic surgery to correct any skeletal deformities. In some cases, medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) may be prescribed to reduce pain and inflammation. In severe cases, blood transfusions may be necessary to replace lost red blood cells.

The risk factors for WT limb-blood syndrome include:

1. Family history of the disorder
2. Genetic mutations in the WT1 gene
3. Exposure to certain environmental toxins
4. Certain medications
5. Radiation exposure
6. Maternal diabetes
7. Maternal smoking during pregnancy

At this time, there is no known cure for WT limb-blood syndrome. Treatment focuses on managing the symptoms and complications associated with the condition. Medications may be prescribed to help manage pain, swelling, and other symptoms. Physical therapy may also be recommended to help maintain joint mobility and strength.