Unicentric Castleman disease (UCD) is a rare disorder of the lymph nodes that is characterized by the enlargement of a single lymph node or a group of lymph nodes in one area of the body. It is caused by an abnormal immune response, which leads to the overproduction of certain proteins in the lymph nodes. Symptoms of UCD can include fever, night sweats, fatigue, and weight loss. Treatment typically involves medications to suppress the immune system and reduce inflammation.

The most common symptoms of Unicentric Castleman disease include:

-Enlarged lymph nodes in the chest, neck, or abdomen
-Fever
-Night sweats
-Fatigue
-Weight loss
-Shortness of breath
-Cough
-Chest pain
-Abdominal pain
-Loss of appetite
-Itching
-Skin rash
-Joint pain
-Muscle aches
-Swollen legs or feet

The exact cause of Unicentric Castleman disease is unknown. However, it is believed to be related to an abnormal immune response, possibly triggered by a virus or other environmental factor.

The main treatment for Unicentric Castleman disease is corticosteroid therapy, which is usually administered intravenously. Other treatments may include chemotherapy, radiation therapy, and monoclonal antibody therapy. Surgery may also be used to remove the affected lymph node. In some cases, a stem cell transplant may be recommended.

1. HIV/AIDS
2. Immunosuppressive medications
3. Certain genetic mutations
4. Exposure to certain viruses, such as HHV-8
5. Older age
6. Male gender
7. Certain ethnicities, such as African-American or Hispanic

At this time, there is no cure for Unicentric Castleman disease. Treatment typically involves medications to reduce inflammation and suppress the immune system. These medications may include corticosteroids, immunosuppressants, and monoclonal antibodies. In some cases, chemotherapy may be used.