T-B+ severe combined immunodeficiency due to CD45 deficiency is a rare, inherited disorder of the immune system. It is caused by a mutation in the CD45 gene, which is responsible for producing a protein called CD45. This protein is essential for the normal functioning of the immune system, and without it, the body is unable to fight off infections. People with this disorder are at risk for recurrent infections, and may require lifelong treatment with antibiotics and other medications.

The symptoms of T-B+ severe combined immunodeficiency due to CD45 deficiency include recurrent infections, failure to thrive, recurrent diarrhea, recurrent fever, and recurrent respiratory infections. Other symptoms may include skin rashes, enlarged lymph nodes, and recurrent ear infections.

T-B+ severe combined immunodeficiency due to CD45 deficiency is caused by mutations in the CD45 gene. This gene is responsible for producing the CD45 protein, which is essential for the development and function of T and B cells. Mutations in the CD45 gene can lead to a decrease in the amount of CD45 protein produced, resulting in a severe combined immunodeficiency.

Treatment for T-B+ severe combined immunodeficiency due to CD45 deficiency typically involves a bone marrow transplant from a compatible donor. This procedure replaces the defective bone marrow with healthy bone marrow that can produce normal immune cells. Other treatments may include intravenous immunoglobulin (IVIG) therapy, which helps to boost the immune system, and gene therapy, which involves introducing a healthy copy of the defective gene into the patient's cells.

1. Genetic mutation: T-B+ severe combined immunodeficiency due to CD45 deficiency is caused by a genetic mutation in the CD45 gene.

2. Family history: Individuals with a family history of T-B+ severe combined immunodeficiency due to CD45 deficiency are at an increased risk of developing the condition.

3. Ethnicity: Individuals of certain ethnic backgrounds, such as Ashkenazi Jews, are more likely to develop T-B+ severe combined immunodeficiency due to CD45 deficiency.

4. Age: T-B+ severe combined immunodeficiency due to CD45 deficiency is more common in infants and young children.

At this time, there is no cure for T-B+ severe combined immunodeficiency due to CD45 deficiency. However, there are treatments available to help manage the condition. These include medications to boost the immune system, such as immunoglobulins, and bone marrow or stem cell transplants. Additionally, supportive care such as antibiotics and antivirals may be used to help prevent and treat infections.