Syndromic orbital border hypoplasia is a rare congenital disorder characterized by underdevelopment of the bones that form the orbital rim of the eye. It is usually associated with other syndromic features, such as craniofacial anomalies, skeletal abnormalities, and intellectual disability.

The most common symptoms of syndromic orbital border hypoplasia include:

-Widely spaced eyes
-Underdeveloped or absent eyebrows
-Underdeveloped or absent eyelashes
-Underdeveloped or absent upper eyelids
-Underdeveloped or absent lower eyelids
-Underdeveloped or absent tear ducts
-Underdeveloped or absent lacrimal glands
-Underdeveloped or absent orbital bones
-Underdeveloped or absent orbital fat
-Underdeveloped or absent orbital muscles
-Underdeveloped or absent orbital septum
-Underdeveloped or absent orbital veins
-Underdeveloped or absent orbital nerves
-Underdeveloped or absent orbital arteries
-Underdeveloped or absent orbital ligaments
-Underdeveloped or absent orbital connective tissue
-Underdeveloped or absent orbital skin
-Underdeveloped or absent orbital fat pads
-Underdeveloped or absent

Syndromic orbital border hypoplasia is a rare condition that is caused by genetic mutations. It is associated with a number of different syndromes, including Treacher Collins Syndrome, Goldenhar Syndrome, and Nager Syndrome. In some cases, the cause of the condition is unknown.

The treatments for Syndromic Orbital Border Hypoplasia vary depending on the severity of the condition and the individual patient. Generally, treatment may include:

1. Surgery to correct the shape of the orbit and improve vision.

2. Eyeglasses or contact lenses to correct vision problems.

3. Medications to reduce inflammation and improve vision.

4. Physical therapy to improve eye movement and coordination.

5. Speech therapy to improve communication skills.

6. Occupational therapy to improve daily living skills.

7. Genetic counseling to discuss the risks and benefits of genetic testing.

1. Genetic mutations
2. Chromosomal abnormalities
3. Maternal diabetes
4. Maternal alcohol consumption
5. Maternal smoking
6. Maternal drug use
7. Maternal exposure to radiation
8. Maternal infections
9. Maternal malnutrition
10. Premature birth

At this time, there is no known cure or medications for Syndromic Orbital Border Hypoplasia. Treatment is focused on managing the symptoms and complications associated with the condition. This may include vision therapy, corrective lenses, and surgery to correct any facial deformities.