Spastic paraplegia type 7 (SPG7) is a rare, inherited neurological disorder that affects the movement of the legs. It is caused by mutations in the SPG7 gene, which is responsible for producing a protein called paraplegin. People with SPG7 experience progressive muscle weakness and stiffness in the legs, which can lead to difficulty walking and balance problems. Other symptoms may include bladder and bowel problems, as well as fatigue. There is currently no cure for SPG7, but physical therapy and medications can help manage symptoms.

The symptoms of Spastic Paraplegia Type 7 (SPG7) vary from person to person, but may include:

- Muscle Stiffness and Spasticity in the legs

- Weakness in the legs

- Difficulty walking

- Abnormal gait

- Difficulty with balance

- Loss of sensation in the legs

- Urinary and/or bowel incontinence

- Muscle wasting in the legs

- Pain in the legs

- Fatigue

- Difficulty with coordination and fine motor skills

Spastic paraplegia type 7 (SPG7) is caused by mutations in the SPG7 gene. This gene provides instructions for making a protein called paraplegin, which is found in the mitochondria of cells. Mutations in the SPG7 gene lead to a decrease in the amount of paraplegin protein, which disrupts the normal function of mitochondria and causes the signs and symptoms of SPG7.

1. Physical therapy: Physical therapy can help improve muscle strength, flexibility, and coordination. It can also help reduce spasticity and improve balance and gait.

2. Medications: Medications such as baclofen, diazepam, and tizanidine can help reduce spasticity and improve muscle control.

3. Surgery: Surgery may be recommended to reduce spasticity and improve muscle control.

4. Assistive devices: Assistive devices such as braces, walkers, and wheelchairs can help improve mobility and independence.

5. Occupational therapy: Occupational therapy can help improve daily living skills and help with activities of daily living.

6. Speech therapy: Speech therapy can help improve communication skills.

1. Genetic mutation in the SPG7 gene
2. Family history of the disorder
3. Age of onset (usually between 10 and 20 years old)
4. Gender (more common in males)
5. Ethnicity (more common in people of Ashkenazi Jewish descent)
6. Exposure to certain environmental toxins or radiation

At this time, there is no known cure for Spastic Paraplegia Type 7. However, there are medications that can help manage the symptoms of the condition. These medications include muscle relaxants, antispasmodics, and medications to reduce pain. Physical therapy and occupational therapy can also help improve mobility and reduce pain.