Short fifth metacarpals-insulin resistance syndrome is a rare genetic disorder characterized by short fifth metacarpals (the bones in the hand between the wrist and the fingers) and insulin resistance. People with this disorder may also have other physical abnormalities, including short stature, facial dysmorphism, and skeletal abnormalities. They may also have intellectual disability, developmental delay, and behavioral problems. Treatment typically involves managing the symptoms and complications of the disorder.

The symptoms of Short fifth metacarpals-insulin resistance syndrome include short fifth metacarpals (the bones in the hand between the wrist and the fingers), insulin resistance, obesity, high blood pressure, high cholesterol, and type 2 diabetes. Other symptoms may include delayed puberty, delayed growth, and developmental delays.

Short fifth metacarpals-insulin resistance syndrome is caused by a mutation in the gene encoding the insulin receptor. This mutation affects the ability of the insulin receptor to bind to insulin, resulting in insulin resistance. This can lead to a variety of symptoms, including short fifth metacarpals, which are the bones in the hand that connect the fingers to the wrist. Other symptoms may include obesity, high blood pressure, and type 2 diabetes.

The treatments for Short fifth metacarpals-insulin resistance syndrome vary depending on the severity of the condition. Generally, treatment focuses on managing the symptoms and preventing complications. This may include lifestyle modifications such as diet and exercise, medications to control blood sugar levels, and supplements to improve insulin sensitivity. In some cases, surgery may be necessary to correct the deformity of the fifth metacarpal. Additionally, physical therapy may be recommended to improve range of motion and strength in the affected hand.

1. Family history of the condition
2. Being of African-American descent
3. Being overweight or obese
4. Having a history of gestational diabetes
5. Having a history of polycystic ovary syndrome (PCOS)
6. Having a history of hypertension
7. Having a history of type 2 diabetes
8. Having a history of metabolic syndrome
9. Having a history of cardiovascular disease
10. Having a history of high cholesterol or triglycerides

Unfortunately, there is no known cure or medications for Short fifth metacarpals-insulin resistance syndrome. Treatment focuses on managing the symptoms and preventing complications. This includes lifestyle changes such as eating a healthy diet, exercising regularly, and maintaining a healthy weight. Medications such as metformin and insulin may also be prescribed to help control blood sugar levels.