Pure Autonomic Failure is a rare neurological disorder that affects the autonomic nervous system, which controls involuntary bodily functions such as heart rate, blood pressure, digestion, and temperature regulation. Symptoms of the disorder include dizziness, lightheadedness, fatigue, and difficulty standing or walking. In some cases, the disorder can also cause bladder and bowel dysfunction. Treatment typically involves medications to help manage symptoms.

The symptoms of Pure Autonomic Failure include:

- Orthostatic hypotension (Dizziness or lightheadedness when standing up)
- Postural tachycardia (rapid heart rate when standing up)
- Urinary retention or incontinence
- Constipation
- Difficulty swallowing
- Blurred vision
- Dry eyes and mouth
- Loss of sweating
- Fatigue
- Sexual dysfunction
- Abnormal pupil responses
- Abnormal blood pressure responses

The exact cause of pure autonomic failure is unknown. However, it is believed to be caused by an autoimmune disorder, where the body's immune system mistakenly attacks healthy cells in the autonomic nervous system. Other possible causes include genetic factors, viral infections, and certain medications.

1. Medications: Medications such as fludrocortisone, midodrine, and desmopressin can help to improve blood pressure and reduce symptoms of Pure Autonomic Failure.

2. Physical Therapy: Physical therapy can help to improve balance, coordination, and strength.

3. Diet and Exercise: Eating a healthy diet and exercising regularly can help to improve overall health and reduce symptoms of Pure Autonomic Failure.

4. Assistive Devices: Assistive devices such as canes, walkers, and wheelchairs can help to improve mobility and reduce the risk of falls.

5. Surgery: In some cases, surgery may be necessary to treat underlying conditions that are causing Pure Autonomic Failure.

1. Age: Pure Autonomic Failure is most commonly seen in people over the age of 50.

2. Gender: Men are more likely to develop Pure Autonomic Failure than women.

3. Family History: Having a family history of Pure Autonomic Failure increases the risk of developing the condition.

4. Certain Medications: Certain medications, such as tricyclic antidepressants, can increase the risk of developing Pure Autonomic Failure.

5. Other Medical Conditions: Having certain medical conditions, such as Parkinson’s disease, can increase the risk of developing Pure Autonomic Failure.

There is no cure for Pure Autonomic Failure, but medications can be used to help manage symptoms. These medications may include medications to help regulate blood pressure, medications to help regulate heart rate, medications to help regulate bladder and bowel function, and medications to help regulate sweating.