Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare neurological disorder characterized by progressive muscle stiffness (rigidity) and involuntary muscle jerks (myoclonus). It is a form of encephalomyelitis, which is an inflammation of the brain and spinal cord. Symptoms of PERM can include muscle stiffness, spasms, tremors, difficulty walking, and difficulty speaking. The cause of PERM is unknown, but it is thought to be an autoimmune disorder. Treatment typically involves medications to reduce inflammation and muscle spasms, physical therapy, and lifestyle modifications.

The symptoms of Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM) include:

- Muscle Stiffness and spasms
- Abnormal movements of the limbs, face, and trunk
- Abnormal posturing of the body
- Difficulty speaking and swallowing
- Cognitive impairment
- Seizures
- Visual disturbances
- Fatigue
- Sleep disturbances
- Autonomic dysfunction
- Pain

The exact cause of Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM) is unknown. However, it is believed to be an autoimmune disorder, meaning that the body’s immune system mistakenly attacks healthy cells in the brain and spinal cord. Other possible causes include genetic mutations, viral infections, and environmental toxins.

1. Medications: Anticonvulsants, such as valproic acid, clonazepam, and levetiracetam, are commonly used to reduce myoclonus and improve muscle tone. Other medications, such as baclofen, tizanidine, and benzodiazepines, may also be used to reduce muscle spasms and rigidity.

2. Physical Therapy: Physical therapy can help improve muscle strength, flexibility, and coordination.

3. Occupational Therapy: Occupational therapy can help improve daily functioning and quality of life.

4. Surgery: Surgery may be recommended in some cases to reduce muscle spasms and improve mobility.

5. Deep Brain Stimulation: Deep brain stimulation (DBS) is a surgical procedure that involves implanting electrodes into the brain to reduce muscle sp

1. Genetic predisposition
2. Exposure to certain viruses
3. Exposure to certain toxins
4. Autoimmune disorders
5. Head trauma
6. Certain medications
7. Seizures
8. Infections
9. Inflammatory conditions
10. Metabolic disorders

There is no cure for Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM). Treatment focuses on managing symptoms and improving quality of life. Medications such as anticonvulsants, muscle relaxants, and antidepressants may be prescribed to help reduce muscle spasms, rigidity, and myoclonus. Physical and occupational therapy may also be recommended to help improve mobility and function.