Unfortunately, there is no cure for Polyhydramnios-megalencephaly-symptomatic epilepsy syndrome. However, medications can be used to help manage the symptoms of the syndrome. These medications may include anticonvulsants, such as phenytoin, carbamazepine, and valproic acid, as well as other medications to help control seizures. Additionally, physical and occupational therapy may be recommended to help improve motor skills and coordination.

1. Maternal diabetes
2. Maternal obesity
3. Maternal hypertension
4. Maternal smoking
5. Maternal age over 35
6. Advanced maternal age
7. Multiple gestation
8. Family history of epilepsy
9. Genetic mutations
10. Exposure to certain medications or toxins during pregnancy

1. Medication: Anti-seizure medications such as phenobarbital, carbamazepine, and valproic acid are often used to control seizures.

2. Surgery: Surgery may be recommended to remove part of the brain that is causing the seizures.

3. Dietary changes: A special diet may be recommended to help control seizures.

4. Physical therapy: Physical therapy can help improve muscle strength and coordination.

5. Occupational therapy: Occupational therapy can help improve daily living skills.

6. Speech therapy: Speech therapy can help improve communication skills.

7. Behavioral therapy: Behavioral therapy can help improve social skills and behavior.

Polyhydramnios-megalencephaly-symptomatic epilepsy syndrome (PMSE) is a rare genetic disorder caused by a mutation in the SLC12A6 gene. This gene is responsible for the production of a protein called solute carrier family 12 member 6 (SLC12A6). This protein is involved in the transport of chloride ions across cell membranes. When the SLC12A6 gene is mutated, it can lead to an imbalance of chloride ions in the brain, which can cause the symptoms associated with PMSE.

The symptoms of Polyhydramnios-Megalencephaly-Symptomatic Epilepsy Syndrome (PMSE) vary from person to person, but may include:

• Seizures
• Developmental delay
• Intellectual disability
• Poor muscle tone
• Abnormal head size (megalencephaly)
• Abnormal facial features
• Abnormalities of the hands and feet
• Abnormalities of the heart and other organs
• Abnormalities of the eyes
• Abnormalities of the ears
• Abnormalities of the urinary tract
• Abnormalities of the gastrointestinal tract
• Abnormalities of the respiratory system
• Abnormalities of the skin
• Abnormalities of the nervous system
• Abnormalities of the immune system
• Abnormalities of the endocrine

Polyhydramnios-megalencephaly-symptomatic epilepsy syndrome (PMSE) is a rare genetic disorder characterized by an abnormally large head size (megalencephaly), an excess of amniotic fluid (polyhydramnios), and seizures (symptomatic epilepsy). It is caused by a mutation in the gene that codes for the enzyme phosphoinositide-3-kinase (PIK3CA). Symptoms of PMSE can include developmental delays, intellectual disability, and movement disorders. Treatment typically involves medications to control seizures and physical and occupational therapy to help with developmental delays.