Neonatal severe primary hyperparathyroidism is a rare disorder that occurs when the parathyroid glands produce too much parathyroid hormone (PTH). This can lead to high levels of calcium in the blood, which can cause a variety of symptoms, including seizures, vomiting, poor feeding, and failure to thrive. Treatment typically involves surgery to remove the affected parathyroid gland(s).

The symptoms of Neonatal severe primary hyperparathyroidism can include:

-High levels of calcium in the blood (hypercalcemia)
-Low levels of phosphate in the blood (hypophosphatemia)
-High levels of parathyroid hormone in the blood (hyperparathyroidism)
-Failure to thrive
-Vomiting
-Dehydration
-Lethargy
-Weakness
-Irritability
-Seizures
-Developmental delay
-Bone deformities
-Kidney stones

Neonatal severe primary hyperparathyroidism is caused by a genetic mutation in the parathyroid hormone receptor gene. This mutation causes the body to produce too much parathyroid hormone, leading to an increase in calcium levels in the blood. Other causes of neonatal severe primary hyperparathyroidism include a family history of the condition, certain medications, and certain medical conditions such as kidney failure.

1. Calcium and Vitamin D supplementation: This is the mainstay of treatment for neonatal severe primary hyperparathyroidism. Calcium and vitamin D supplementation can help to reduce the levels of parathyroid hormone and calcium in the blood.

2. Surgery: Surgery is the only definitive treatment for neonatal severe primary hyperparathyroidism. The goal of surgery is to remove the abnormal parathyroid gland or glands.

3. Medications: Medications such as bisphosphonates and calcimimetics may be used to help reduce the levels of parathyroid hormone and calcium in the blood.

4. Dialysis: Dialysis may be necessary in some cases to help reduce the levels of calcium and parathyroid hormone in the blood.

1. Maternal hyperparathyroidism
2. Maternal vitamin D deficiency
3. Maternal calcium deficiency
4. Maternal hypoparathyroidism
5. Maternal hypercalcemia
6. Maternal hypercalciuria
7. Maternal hypomagnesemia
8. Maternal hyperphosphatemia
9. Maternal hypophosphatemia
10. Maternal hypervitaminosis D
11. Maternal hypovitaminosis D
12. Maternal hyperthyroidism
13. Maternal hypothyroidism
14. Maternal renal insufficiency
15. Maternal diabetes mellitus
16. Maternal obesity
17. Maternal smoking
18. Maternal alcohol consumption
19. Maternal drug use
20. Prematurity
21. Low

At this time, there is no cure for Neonatal severe primary hyperparathyroidism. Treatment typically involves medications to control calcium levels and to reduce the activity of the parathyroid glands. These medications may include calcitriol, calcium carbonate, and bisphosphonates. In some cases, surgery may be necessary to remove the affected parathyroid gland.