Nail-patella-like renal disease is a rare genetic disorder that affects the kidneys. It is characterized by the presence of small, irregularly shaped nails, patella (kneecap) deformities, and kidney abnormalities. People with this disorder may experience proteinuria (excess protein in the urine), hypertension (high blood pressure), and chronic kidney disease.

The symptoms of nail-patella-like renal disease can vary from person to person, but some of the most common symptoms include:

- Abnormalities of the nails, such as missing or malformed nails
- Abnormalities of the kneecaps, such as missing or malformed kneecaps
- Abnormalities of the elbows, such as missing or malformed elbows
- Abnormalities of the hips, such as hip dysplasia
- Abnormalities of the eyes, such as glauComa or cataracts
- High blood pressure
- Proteinuria (excess protein in the urine)
- Kidney stones
- Kidney failure
- Abnormalities of the urinary tract, such as vesicoureteral reflux
- Abnormalities of the heart, such as

Nail-patella-like renal disease is caused by mutations in the LMX1B gene. This gene is responsible for producing a protein that helps regulate the development of the kidneys, bones, and nails. Mutations in this gene can lead to the development of the disease.

Treatments for Nail-patella-like renal disease vary depending on the severity of the condition. Treatment options may include:

1. Medications: Non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to reduce inflammation and pain.

2. Surgery: Surgery may be necessary to repair any damage to the kidneys or to remove any cysts or tumors.

3. Dialysis: Dialysis may be necessary if the kidneys are severely damaged.

4. Kidney transplant: A kidney transplant may be necessary if the kidneys are no longer functioning properly.

5. Physical therapy: Physical therapy may be recommended to help improve mobility and strength.

6. Dietary changes: Dietary changes may be necessary to help manage symptoms and reduce the risk of complications.

1. Family history: Nail-patella-like renal disease is an inherited disorder, so having a family history of the condition increases the risk of developing it.

2. Age: The risk of developing nail-patella-like renal disease increases with age.

3. Gender: Men are more likely to develop nail-patella-like renal disease than women.

4. Ethnicity: People of European descent are more likely to develop nail-patella-like renal disease than other ethnicities.

There is no cure for nail-patella-like renal disease, but medications can be used to manage the symptoms. These medications include diuretics, ACE inhibitors, and angiotensin receptor blockers to help control blood pressure, and calcium channel blockers to reduce the risk of kidney stones. Additionally, medications such as corticosteroids and immunosuppressants may be used to reduce inflammation and slow the progression of the disease.