Inherited congenital spastic tetraplegia is a rare neurological disorder that is caused by a genetic mutation. It is characterized by spasticity (stiffness and difficulty with movement) in all four limbs, as well as intellectual disability and seizures. It is usually diagnosed in infancy or early childhood. Treatment typically includes physical and occupational therapy, medications, and sometimes surgery.

The symptoms of Inherited congenital spastic tetraplegia vary depending on the severity of the condition, but may include:

- Muscle Stiffness and Spasticity in all four limbs

- Poor coordination and balance

- Difficulty walking or crawling

- Abnormal gait

- Difficulty with fine motor skills

- Poor hand-eye coordination

- Difficulty with speech and language

- Intellectual disability

- Seizures

- Vision and hearing problems

- Abnormal curvature of the spine (scoliosis)

- Abnormal curvature of the feet (clubfoot)

Inherited congenital spastic tetraplegia is caused by genetic mutations that affect the development of the nervous system. These mutations can be inherited from a parent or can occur spontaneously. Common causes of inherited congenital spastic tetraplegia include mutations in the SPG11, SPG7, and SPG20 genes. Other causes include chromosomal abnormalities, such as Down syndrome, and metabolic disorders, such as Leigh syndrome.

1. Physical therapy: Physical therapy can help improve muscle strength, coordination, and range of motion.

2. Occupational therapy: Occupational therapy can help improve fine motor skills, such as writing and using utensils.

3. Speech therapy: Speech therapy can help improve communication skills.

4. Medications: Medications can help reduce spasticity and improve muscle control.

5. Surgery: Surgery may be recommended to correct any underlying structural issues that may be causing the spasticity.

6. Assistive devices: Assistive devices, such as wheelchairs, can help improve mobility.

1. Genetic mutations: Mutations in certain genes, such as the SPG11, SPG7, and SPG20 genes, have been linked to inherited congenital spastic tetraplegia.

2. Family history: Having a family history of inherited congenital spastic tetraplegia increases the risk of developing the condition.

3. Maternal infections: Maternal infections during pregnancy, such as rubella, cytomegalovirus, and toxoplasmosis, can increase the risk of inherited congenital spastic tetraplegia.

4. Maternal drug use: Maternal drug use during pregnancy, such as alcohol, tobacco, and certain medications, can increase the risk of inherited congenital spastic tetraplegia.

5. Premature birth: Premature birth can

At this time, there is no cure for inherited congenital spastic tetraplegia. However, there are medications and therapies that can help manage the symptoms. These include medications to reduce muscle spasticity, physical therapy to help improve mobility, and occupational therapy to help with daily activities.