Huntington disease-like 3 (HDL3) is a rare, inherited neurological disorder that is similar to Huntington disease (HD). HDL3 is caused by a mutation in the same gene that causes HD, but the mutation is different. Symptoms of HDL3 include movement problems, cognitive decline, and psychiatric symptoms. There is currently no cure for HDL3, but treatments are available to help manage symptoms.

1. Uncontrolled movements, such as jerking, twitching, or writhing
2. Cognitive decline, including difficulty with concentration, memory, and decision-making
3. Behavioral changes, such as depression, irritability, and impulsivity

1. Genetic mutation: Huntington disease is caused by a mutation in the huntingtin gene, which is located on chromosome 4. The mutation causes an abnormal form of the huntingtin protein to be produced, which leads to the development of the disease.

2. Inheritance: Huntington disease is an autosomal dominant disorder, meaning that it is inherited from one parent. If one parent has the mutated gene, there is a 50% chance that the child will inherit the gene and develop the disease.

3. Environmental factors: While the exact cause of Huntington disease is unknown, environmental factors such as exposure to certain toxins or viruses may increase the risk of developing the disease.

1. Medications: Medications can help manage some of the symptoms of Huntington disease-like 3, such as chorea, depression, and anxiety. These medications include antipsychotics, antidepressants, and anticonvulsants.

2. Physical Therapy: Physical therapy can help improve balance, coordination, and mobility.

3. Speech Therapy: Speech therapy can help improve communication skills and swallowing difficulties.

4. Occupational Therapy: Occupational therapy can help improve daily living skills and activities.

5. Nutritional Support: Nutritional support can help maintain a healthy weight and provide adequate nutrition.

6. Genetic Counseling: Genetic counseling can help individuals and families understand the risks associated with Huntington disease-like 3 and provide support.

1. Age: The risk of developing Huntington disease-like 3 increases with age.

2. Family history: Having a family history of Huntington disease-like 3 increases the risk of developing the condition.

3. Genetic mutations: Certain genetic mutations can increase the risk of developing Huntington disease-like 3.

4. Ethnicity: People of certain ethnic backgrounds, such as Ashkenazi Jewish, are more likely to develop Huntington disease-like 3.

5. Gender: Men are more likely to develop Huntington disease-like 3 than women.

Unfortunately, there is no cure for Huntington disease-like 3. However, medications can be used to help manage the symptoms of the condition. These medications may include antipsychotics, antidepressants, anticonvulsants, and other medications to help with movement and cognitive problems. Additionally, physical, occupational, and speech therapy can help improve quality of life.