Hereditary Multiple Osteochondromas (HMO) is a rare genetic disorder characterized by the growth of multiple benign (non-cancerous) bone tumors (osteochondromas) on the long bones of the body. These tumors can cause pain, deformity, and disability. HMO is caused by a mutation in the EXT1 gene, which is responsible for the production of a protein that helps regulate the growth of cartilage.

The most common symptom of Hereditary Multiple Osteochondromas is the presence of multiple bony growths (osteochondromas) on the long bones of the body, such as the arms and legs. These growths can range in size from a few millimeters to several centimeters in diameter. Other symptoms may include pain, swelling, and Stiffness in the affected area, as well as a decreased range of motion. In some cases, the growths may cause deformity of the affected limb.

Hereditary Multiple Osteochondromas (HMO) is a rare genetic disorder caused by a mutation in the EXT1 gene. This gene is responsible for the production of a protein that helps regulate the growth of cartilage. When the EXT1 gene is mutated, it can cause the formation of multiple benign bone tumors called osteochondromas. These tumors can cause pain, deformity, and other complications. There is no known cure for HMO, but treatments are available to manage symptoms and reduce the risk of complications.

The primary treatment for Hereditary Multiple Osteochondromas is surgical removal of the affected bones. This is usually done to reduce pain and prevent further complications. Other treatments may include physical therapy, medications to reduce pain and inflammation, and bracing to support the affected area. In some cases, radiation therapy may be used to shrink the tumors.

1. Having a family history of Hereditary Multiple Osteochondromas (HMO).
2. Having a mutation in the EXT1 or EXT2 gene.
3. Being male.
4. Being of Caucasian descent.
5. Having a history of growth hormone therapy.

There is no cure for hereditary multiple osteochondromas, but medications can be used to manage symptoms. Nonsteroidal anti-inflammatory drugs (NSAIDs) can be used to reduce pain and inflammation. Corticosteroids can also be used to reduce inflammation. Surgery may be necessary to remove large or painful osteochondromas.