Familial rhabdoid tumor is a rare, aggressive type of cancer that typically affects children under the age of two. It is characterized by the presence of large, malignant cells that have a rhabdoid appearance under the microscope. This type of tumor is usually found in the brain, kidneys, or soft tissues of the body. It is caused by a mutation in the SMARCB1 gene, which is inherited in an autosomal dominant manner. Treatment typically involves surgery, chemotherapy, and radiation therapy.

The most common symptoms of familial rhabdoid tumor include:

-Abdominal pain
-Abdominal swelling
-Fever
-Weight loss
-Lethargy
-Vomiting
-Diarrhea
-Blood in the urine
-Lumps or masses in the abdomen
-Jaundice
-Enlarged liver or spleen
-Breathing difficulties
-Seizures
-Headaches
-Vision changes

The exact cause of familial rhabdoid tumor is unknown. However, it is believed to be caused by a mutation in the SMARCB1 gene, which is responsible for controlling cell growth and division. Mutations in this gene can lead to the uncontrolled growth of cells, which can form a tumor.

The treatment for familial rhabdoid tumor depends on the location and stage of the tumor. Treatment typically includes surgery to remove the tumor, followed by chemotherapy and/or radiation therapy. In some cases, targeted therapy may be used to target specific genetic mutations associated with the tumor. Clinical trials may also be available for some patients.

1. Having a family history of rhabdoid tumors
2. Having a genetic mutation in the SMARCB1 gene
3. Having a genetic mutation in the SMARCA4 gene
4. Having a genetic mutation in the INI1 gene
5. Having a genetic mutation in the TSC2 gene
6. Having a genetic mutation in the TP53 gene
7. Having a genetic mutation in the PTEN gene
8. Having a genetic mutation in the NF1 gene
9. Having a genetic mutation in the RB1 gene
10. Having a genetic mutation in the STAG2 gene
11. Having a genetic mutation in the SETD2 gene
12. Having a genetic mutation in the KDM6A gene
13. Having a genetic mutation in the KMT2D gene
14. Having a genetic

Unfortunately, there is no known cure for familial rhabdoid tumor. Treatment typically involves surgery to remove the tumor, chemotherapy, and radiation therapy. Medications such as vincristine, cisplatin, and etoposide may be used to help reduce the size of the tumor and slow its growth.