Congenital plasminogen deficiency is a rare inherited disorder that affects the body's ability to break down proteins. It is caused by a mutation in the PLG gene, which provides instructions for making the plasminogen protein. This protein is involved in the breakdown of proteins in the body, and when it is deficient, proteins can accumulate in the blood and tissues, leading to a variety of symptoms. Symptoms may include recurrent infections, delayed wound healing, and abnormal bleeding. Treatment typically involves replacing the missing plasminogen protein with a medication.

The symptoms of Congenital Plasminogen Deficiency vary depending on the type of deficiency. Common symptoms include recurrent infections, delayed wound healing, and abnormal bleeding. Other symptoms may include recurrent episodes of deep vein thrombosis, pulmonary embolism, and recurrent miscarriages.

Congenital plasminogen deficiency is caused by mutations in the PLG gene, which provides instructions for making the plasminogen protein. This protein is involved in the breakdown of blood clots and other proteins in the body. Mutations in the PLG gene can lead to a decrease in the amount of plasminogen protein produced, resulting in a deficiency of this protein.

The primary treatment for Congenital Plasminogen Deficiency is replacement therapy with plasminogen concentrate. This is usually administered intravenously, and may be supplemented with other treatments such as antibiotics, antifibrinolytic agents, and anticoagulants. Surgery may also be necessary to remove any affected tissue. In some cases, gene therapy may be used to replace the defective gene responsible for the condition.

1. Family history of the disorder
2. Maternal exposure to certain medications, such as anticonvulsants, during pregnancy
3. Maternal infection during pregnancy
4. Maternal diabetes
5. Maternal obesity
6. Advanced maternal age
7. Low birth weight
8. Premature birth

There is no cure for Congenital Plasminogen Deficiency, but medications can be used to help manage the symptoms. These medications include plasminogen replacement therapy, anticoagulants, and anti-inflammatory drugs. Additionally, lifestyle changes such as avoiding smoking and maintaining a healthy diet can help reduce the risk of complications.