Childhood-onset benign chorea with striatal involvement is a rare neurological disorder characterized by involuntary, rapid, jerky movements (chorea) that usually begin in childhood. It is caused by an abnormal accumulation of iron in the brain, specifically in the striatum, which is a part of the basal ganglia. Symptoms may include difficulty walking, difficulty speaking, and difficulty with fine motor skills. Treatment typically involves medications to reduce the amount of iron in the brain.

The symptoms of Childhood-onset benign chorea with striatal involvement include:

-Involuntary, rapid, jerky movements of the face, arms, and legs
-Difficulty with coordination and balance
-Difficulty with fine motor skills
-Difficulty with speech
-Difficulty with swallowing
-Behavioral changes, such as irritability, aggression, and hyperactivity
-Learning difficulties
-Seizures
-Sleep disturbances

The exact cause of Childhood-onset benign chorea with striatal involvement is unknown. However, it is believed to be caused by a combination of genetic and environmental factors. Possible causes include:

1. Genetic mutations: Certain genetic mutations have been linked to this condition, including those in the genes SLC2A1, SLC6A3, and SLC6A4.

2. Infections: Certain infections, such as those caused by the Epstein-Barr virus, may be linked to this condition.

3. Autoimmune disorders: Autoimmune disorders, such as systemic lupus erythematosus, may be linked to this condition.

4. Environmental factors: Exposure to certain environmental toxins, such as lead, may be linked to this condition.

1. Medication: Medications such as haloperidol, risperidone, and clonazepam can be used to reduce the severity of the chorea.

2. Physical Therapy: Physical therapy can help improve coordination and balance, as well as reduce the severity of the chorea.

3. Occupational Therapy: Occupational therapy can help improve daily functioning and reduce the impact of the chorea on daily activities.

4. Speech Therapy: Speech therapy can help improve communication and reduce the impact of the chorea on speech.

5. Cognitive Behavioral Therapy: Cognitive behavioral therapy can help improve coping skills and reduce the impact of the chorea on behavior.

6. Diet and Nutrition: A healthy diet and adequate nutrition can help reduce the severity of the chorea.

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1. Genetic predisposition: Certain genetic mutations have been linked to an increased risk of developing childhood-onset benign chorea with striatal involvement.

2. Exposure to toxins: Exposure to certain toxins, such as lead, may increase the risk of developing this condition.

3. Infections: Certain infections, such as Lyme disease, may increase the risk of developing this condition.

4. Autoimmune disorders: Having an autoimmune disorder, such as lupus, may increase the risk of developing this condition.

5. Family history: Having a family history of this condition may increase the risk of developing it.

Yes, there are medications that can be used to treat Childhood-onset benign chorea with striatal involvement. These medications include anticonvulsants, antipsychotics, and dopamine agonists. Additionally, physical and occupational therapy can help to reduce the severity of the symptoms.