Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2) is a rare type of leukemia that is characterized by the presence of two different types of leukemia cells in the same patient. It is caused by a chromosomal translocation between chromosomes 9 and 22, which results in the fusion of two genes, BCR and ABL1. This fusion gene produces an abnormal protein that causes uncontrolled cell growth and leads to the development of leukemia. Treatment for this type of leukemia typically involves chemotherapy and/or stem cell transplantation.

The symptoms of Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2) can vary depending on the type of leukemia present. Generally, symptoms may include fatigue, fever, weight loss, night sweats, bone pain, and easy bruising or bleeding. Other symptoms may include an enlarged spleen, swollen lymph nodes, and anemia.

Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2) is caused by a chromosomal translocation between chromosomes 9 and 22, which results in the fusion of the BCR and ABL1 genes. This fusion gene produces an abnormal protein that causes uncontrolled cell growth and leads to leukemia. Other causes of this type of leukemia include exposure to radiation, certain chemotherapy drugs, and certain genetic disorders.

The treatment for Mixed Phenotype Acute Leukemia with t(9;22)(q34.1;q11.2) typically involves a combination of chemotherapy, radiation therapy, and stem cell transplantation. Chemotherapy is used to reduce the number of leukemia cells in the body and to prepare the body for a stem cell transplant. Radiation therapy is used to target and destroy cancer cells in specific areas of the body. Finally, a stem cell transplant is used to replace the damaged bone marrow with healthy stem cells.

1. Exposure to radiation
2. Exposure to certain chemicals
3. Genetic predisposition
4. Certain viral infections
5. Certain inherited genetic disorders
6. Previous chemotherapy or radiation therapy
7. Exposure to certain drugs
8. Exposure to certain environmental toxins
9. Family history of leukemia

At this time, there is no known cure for Mixed Phenotype Acute Leukemia with t(9;22)(q34.1;q11.2). Treatment typically involves chemotherapy and/or stem cell transplantation. Medications used to treat this type of leukemia may include corticosteroids, vincristine, cytarabine, daunorubicin, and imatinib.