Microcephaly-facio-cardio-skeletal syndrome, Hadziselimovic type (MFCS-H) is a rare genetic disorder characterized by microcephaly (abnormally small head size), facial dysmorphism (abnormal facial features), cardiac defects, and skeletal abnormalities. It is caused by a mutation in the gene encoding the protein filamin A (FLNA). Symptoms may include intellectual disability, seizures, and developmental delay. Treatment is symptomatic and supportive.

The symptoms of Microcephaly-facio-cardio-skeletal syndrome, Hadziselimovic type, include:

-Microcephaly (abnormally Small head size)
-Facial dysmorphism (abnormal facial features)
-Cardiac defects (heart defects)
-Skeletal abnormalities (abnormalities of the bones and joints)
-Developmental delay
-Seizures
-Hearing loss
-Feeding difficulties
-Growth retardation
-Hypotonia (low muscle tone)
-Intellectual disability
-Behavioral problems
-Speech delay

Microcephaly-facio-cardio-skeletal syndrome, Hadziselimovic type is a rare genetic disorder caused by a mutation in the PEX1 gene. This gene is responsible for the production of a protein called peroxisome biogenesis factor 1, which is essential for the formation and functioning of peroxisomes. Peroxisomes are organelles that are involved in a variety of metabolic processes, including the breakdown of fatty acids and the production of energy. Mutations in the PEX1 gene lead to a decrease in the production of this protein, resulting in the development of the symptoms associated with this disorder.

Unfortunately, there is no known cure for Microcephaly-facio-cardio-skeletal syndrome, Hadziselimovic type. Treatment is focused on managing the symptoms and providing supportive care. This may include physical therapy, occupational therapy, speech therapy, and other interventions to help the individual reach their highest level of functioning. Additionally, medications may be prescribed to help manage seizures, muscle spasms, and other symptoms. Genetic counseling may also be recommended to help families understand the condition and plan for the future.

1. Genetic mutation: The most common cause of Microcephaly-facio-cardio-skeletal syndrome, Hadziselimovic type is a mutation in the gene called MCPH1.

2. Family history: Having a family history of the condition increases the risk of developing Microcephaly-facio-cardio-skeletal syndrome, Hadziselimovic type.

3. Environmental factors: Exposure to certain environmental toxins or radiation may increase the risk of developing Microcephaly-facio-cardio-skeletal syndrome, Hadziselimovic type.

4. Age: The condition is more common in infants and young children.

Unfortunately, there is no known cure or medications for Microcephaly-facio-cardio-skeletal syndrome, Hadziselimovic type. Treatment is focused on managing the symptoms and providing supportive care. This may include physical therapy, occupational therapy, speech therapy, and other interventions to help the individual reach their highest level of functioning.