Methotrexate toxicity is a condition that occurs when a person takes too much of the drug methotrexate. This drug is used to treat certain types of cancer, autoimmune diseases, and other conditions. Symptoms of methotrexate toxicity can include nausea, vomiting, abdominal pain, diarrhea, fatigue, fever, and rash. In severe cases, it can lead to liver damage, kidney failure, and even death.

Symptoms of Methotrexate toxicity can include: nausea, vomiting, abdominal pain, diarrhea, fatigue, fever, headache, dizziness, confusion, blurred vision, seizures, and difficulty breathing. In severe cases, it can cause liver and kidney damage, anemia, and even death.

Methotrexate toxicity can be caused by a variety of factors, including:

1. Overdose: Taking too much of the medication can lead to toxicity.

2. Interactions with other medications: Certain medications can interact with methotrexate and increase the risk of toxicity.

3. Kidney or liver disease: People with kidney or liver disease may be more likely to experience toxicity from methotrexate.

4. Alcohol use: Drinking alcohol while taking methotrexate can increase the risk of toxicity.

5. Age: Older adults may be more likely to experience toxicity from methotrexate.

6. Poor nutrition: People who are malnourished may be more likely to experience toxicity from methotrexate.

1. Folate supplementation: Folate supplementation is often recommended to reduce the risk of methotrexate toxicity.

2. Leucovorin rescue: Leucovorin rescue is a treatment that involves administering high doses of folinic acid (a form of folic acid) to counteract the toxic effects of methotrexate.

3. Hydration: Hydration is important to help flush out the methotrexate from the body.

4. Dialysis: Dialysis may be necessary in cases of severe methotrexate toxicity.

5. Antidote: An antidote, such as aminopterin, may be used to counteract the toxic effects of methotrexate.

1. High dose of methotrexate
2. Renal impairment
3. Liver dysfunction
4. Alcohol consumption
5. Age (elderly patients are more susceptible)
6. Concomitant use of other drugs that can increase methotrexate levels
7. Poor compliance with folate supplementation
8. Poor nutrition
9. Smoking
10. Genetic predisposition

Yes, there are medications that can be used to treat Methotrexate toxicity. These include leucovorin, which is a form of folic acid, and other medications such as folinic acid, thymidine, and 5-fluorouracil. Additionally, supportive care such as hydration and electrolyte replacement may be necessary.