Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency is a rare genetic disorder that results in an increased susceptibility to certain types of mycobacterial infections, such as tuberculosis. People with this disorder have a complete deficiency of the IL12B gene, which is responsible for producing the cytokine interleukin-12 (IL-12). Without IL-12, the body is unable to mount an effective immune response to mycobacterial infections, leading to an increased risk of developing serious and potentially life-threatening infections.

The symptoms of Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency include recurrent and severe mycobacterial infections, such as tuberculosis, leprosy, and atypical mycobacterial infections. Other symptoms may include fever, night sweats, weight loss, fatigue, and anemia. In some cases, patients may also experience joint pain, skin rashes, and lymphadenopathy.

Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency is caused by mutations in the IL12B gene. This gene encodes the interleukin-12B protein, which is involved in the body's immune response to mycobacterial infections. Mutations in this gene can lead to a complete deficiency of the IL12B protein, resulting in an impaired immune response and an increased susceptibility to mycobacterial infections.

1. Antibiotic therapy: Antibiotics such as isoniazid, rifampin, ethambutol, and pyrazinamide are used to treat active infections.

2. Immunomodulatory therapy: Immunomodulatory agents such as interferon-gamma, interleukin-12, and interleukin-23 can be used to stimulate the immune system and help fight off infections.

3. Vaccination: Vaccines can be used to help prevent infections.

4. Nutritional support: Proper nutrition is important for maintaining a healthy immune system.

5. Gene therapy: Gene therapy is a potential treatment option for some forms of Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency.

1. Family history of Mendelian susceptibility to mycobacterial diseases
2. Genetic mutation in the IL12B gene
3. Immunodeficiency
4. Exposure to mycobacterial infections
5. Age (children are more susceptible)
6. Low socioeconomic status
7. Poor nutrition
8. Poor hygiene
9. Living in areas with high prevalence of mycobacterial infections

At this time, there is no cure for Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency. However, there are medications that can help manage the symptoms and reduce the risk of complications. These medications include antibiotics, immunosuppressants, and interferon gamma. Additionally, lifestyle modifications such as avoiding contact with people who have active tuberculosis, getting vaccinated against tuberculosis, and avoiding contact with animals that may carry mycobacteria can help reduce the risk of infection.