Maternally Inherited Leigh Syndrome (MILS) is a rare, inherited mitochondrial disorder that affects the central nervous system. It is caused by a mutation in the mitochondrial DNA, which is passed down from the mother to her children. Symptoms of MILS include developmental delay, seizures, vision and hearing loss, and muscle weakness.

NARP Syndrome (Neuropathy, Ataxia, and Retinitis Pigmentosa) is a rare, inherited mitochondrial disorder that affects the central nervous system. It is caused by a mutation in the mitochondrial DNA, which is passed down from the mother to her children. Symptoms of NARP Syndrome include progressive muscle weakness, ataxia, vision loss, hearing loss, and seizures.

Maternally Inherited Leigh Syndrome:

Symptoms of Maternally Inherited Leigh Syndrome (MILS) can vary from person to person, but typically include:

• Developmental delay

• Poor muscle tone

• Seizures

• Abnormal eye movements

• Difficulty swallowing

• Difficulty breathing

• Poor coordination

• Abnormalities in the brain

• Abnormalities in the heart

• Abnormalities in the liver

• Abnormalities in the kidneys

• Abnormalities in the pancreas

• Abnormalities in the muscles

• Abnormalities in the eyes

• Abnormalities in the ears

• Abnormalities in the bones

• Abnormalities in the skin

• Abnormalities in

Maternally Inherited Leigh Syndrome (MILS) is caused by mutations in the mitochondrial DNA. NARP Syndrome (Neuropathy, Ataxia, and Retinitis Pigmentosa) is caused by mutations in the mitochondrial ATPase 6 gene.

Maternally Inherited Leigh Syndrome:

1. Dietary modifications: A low-protein diet may be recommended to reduce the amount of toxic metabolites in the body.

2. Vitamin supplementation: Vitamin B12, thiamine, and coenzyme Q10 may be recommended to help reduce symptoms.

3. Antioxidants: Antioxidants such as vitamin E, selenium, and coenzyme Q10 may be recommended to help reduce oxidative stress.

4. Medications: Medications such as acetazolamide, topiramate, and zonisamide may be recommended to help reduce symptoms.

5. Surgery: Surgery may be recommended to help reduce symptoms.

NARP Syndrome:

1. Dietary modifications: A low-protein diet may be recommended to reduce the amount of toxic metabolites in

Maternally Inherited Leigh Syndrome:

1. Mutation in the mitochondrial DNA
2. Inheritance from a mother with a mitochondrial DNA mutation
3. Family history of Leigh Syndrome

NARP Syndrome:

1. Mutation in the mitochondrial DNA
2. Inheritance from a mother with a mitochondrial DNA mutation
3. Family history of NARP Syndrome
4. Exposure to certain environmental toxins or drugs

Maternally Inherited Leigh Syndrome (MILS) is a rare mitochondrial disorder that is caused by a mutation in the mitochondrial DNA. There is currently no cure for MILS, but medications can be used to help manage the symptoms. These medications include anticonvulsants, muscle relaxants, and medications to help with breathing.

NARP Syndrome (Neuropathy, Ataxia, and Retinitis Pigmentosa) is a rare genetic disorder that is caused by a mutation in the mitochondrial DNA. There is currently no cure for NARP Syndrome, but medications can be used to help manage the symptoms. These medications include anticonvulsants, muscle relaxants, and medications to help with vision and breathing.