About Malignant Hyperthermia

What is Malignant Hyperthermia?

Malignant hyperthermia is a rare, inherited disorder that causes a person's muscles to become rigid and their body temperature to rise rapidly in response to certain drugs used during general anesthesia. Symptoms of malignant hyperthermia include muscle rigidity, rapid heart rate, high fever, and increased carbon dioxide levels in the blood. If left untreated, malignant hyperthermia can lead to organ failure and death. Treatment typically involves administering dantrolene, a medication that relaxes the muscles and lowers body temperature.

What are the symptoms of Malignant Hyperthermia?

The symptoms of Malignant Hyperthermia include:

-Rapid rise in body temperature
-Muscle rigidity
-Rapid heart rate
-Rapid breathing
-Excessive sweating
-Confusion
-Dark urine
-Abnormal heart rhythm
-Low blood pressure
-Seizures
-Cardiac arrest

What are the causes of Malignant Hyperthermia?

Malignant hyperthermia is a rare, inherited disorder that is triggered by certain medications used during general anesthesia. It is caused by a genetic mutation in the ryanodine receptor, which is responsible for controlling the release of calcium from the muscle cells. This mutation causes the muscle cells to become overly sensitive to certain medications, leading to an excessive release of calcium and an increase in muscle contractions. This can lead to a rapid rise in body temperature, increased heart rate, and other life-threatening complications.

What are the treatments for Malignant Hyperthermia?

The primary treatment for malignant hyperthermia is to stop the triggering agent, such as the anesthetic, and to provide supportive care. This includes cooling the patient, providing oxygen, and administering medications to reduce muscle contractions. Other treatments may include administering dantrolene sodium, a muscle relaxant, and intravenous fluids. In some cases, dialysis may be necessary to remove toxins from the body.

What are the risk factors for Malignant Hyperthermia?

1. Family history of Malignant Hyperthermia
2. Certain genetic mutations
3. Exposure to certain anesthetic agents
4. Certain medical conditions, such as central core disease, myotonia congenita, and Duchenne muscular dystrophy
5. Male gender
6. Age (more common in children and young adults)
7. Certain medications, such as succinylcholine and halothane

Is there a cure/medications for Malignant Hyperthermia?

Yes, there is a medication called dantrolene sodium that can be used to treat malignant hyperthermia. It works by blocking the release of calcium from the muscle cells, which helps to reduce the muscle contractions and spasms associated with the condition. Additionally, supportive care such as cooling and oxygen therapy may be used to help manage the symptoms.