About Lisch epithelial corneal dystrophy

What is Lisch epithelial corneal dystrophy?

Lisch epithelial corneal dystrophy is a rare, inherited eye disorder that affects the cornea, the clear outer layer of the eye. It is characterized by the presence of small, gray-white deposits called guttae, which are made up of lipids and proteins. These deposits can cause vision problems, including blurred vision, glare, and light sensitivity. Treatment typically involves the use of artificial tears and lubricating eye drops to reduce symptoms. In some cases, corneal transplantation may be necessary.

What are the symptoms of Lisch epithelial corneal dystrophy?

The most common symptoms of Lisch epithelial corneal dystrophy include:

-Painless, grayish-white spots on the cornea

-Blurred vision

-Sensitivity to light

-Redness of the eyes

-Tearing

-Itching

-Burning sensation in the eyes

-Decreased vision

What are the causes of Lisch epithelial corneal dystrophy?

Lisch epithelial corneal dystrophy is caused by a mutation in the CHST6 gene, which is responsible for the production of a protein called chondroitin sulfate N-acetylgalactosaminyltransferase 6. This protein is involved in the production of a type of sugar molecule called chondroitin sulfate, which is important for the structure and function of the cornea.

What are the treatments for Lisch epithelial corneal dystrophy?

1. Eyeglasses or contact lenses: Eyeglasses or contact lenses can help improve vision in people with Lisch epithelial corneal dystrophy.

2. Corneal transplant: A corneal transplant may be recommended if the vision is significantly impaired.

3. Intacs: Intacs are small plastic rings that are surgically implanted in the cornea to help improve vision.

4. Phototherapeutic keratectomy (PTK): PTK is a procedure that uses a laser to remove the abnormal cells from the cornea.

5. Corneal collagen cross-linking: This procedure uses ultraviolet light and riboflavin to strengthen the cornea and reduce the risk of further damage.

What are the risk factors for Lisch epithelial corneal dystrophy?

1. Genetic predisposition: Lisch epithelial corneal dystrophy is an autosomal dominant disorder, meaning that it is inherited from one parent.

2. Age: The condition is more common in adults, although it can occur in children.

3. Gender: The condition is more common in males than females.

4. Ethnicity: The condition is more common in people of Asian descent.

Is there a cure/medications for Lisch epithelial corneal dystrophy?

At this time, there is no known cure for Lisch epithelial corneal dystrophy. However, there are medications that can be used to manage the symptoms of the condition. These include topical lubricants, anti-inflammatory medications, and antibiotics. In some cases, surgery may be recommended to improve vision.