Lethal hydranencephaly-diaphragmatic hernia syndrome is a rare genetic disorder characterized by the absence of most of the brain's cerebral hemispheres, a diaphragmatic hernia, and other malformations. It is a fatal condition, with most affected infants dying shortly after birth.

The symptoms of Lethal hydranencephaly-diaphragmatic hernia syndrome include:

-Severe developmental delay
-Seizures
-Feeding difficulties
-Respiratory distress
-Hydranencephaly (absence of the cerebral hemispheres)
-Diaphragmatic hernia
-Gastrointestinal malformations
-Cardiac malformations
-Abnormalities of the eyes, ears, and face
-Abnormalities of the hands and feet
-Abnormalities of the genitalia
-Abnormalities of the spine
-Abnormalities of the kidneys and urinary tract
-Abnormalities of the skin

The exact cause of Lethal hydranencephaly-diaphragmatic hernia syndrome is unknown. It is thought to be caused by a combination of genetic and environmental factors. Possible causes include chromosomal abnormalities, genetic mutations, and exposure to certain toxins or infections during pregnancy.

Unfortunately, there is no known cure for Lethal hydranencephaly-diaphragmatic hernia syndrome. Treatment is focused on providing supportive care to help manage symptoms and improve quality of life. This may include physical therapy, occupational therapy, speech therapy, and nutritional support. Medications may also be prescribed to help manage seizures, pain, and other symptoms.

1. Maternal diabetes
2. Maternal obesity
3. Maternal smoking
4. Maternal alcohol consumption
5. Maternal age over 35
6. Maternal exposure to certain medications
7. Maternal exposure to environmental toxins
8. Family history of genetic disorders
9. Advanced paternal age
10. Advanced maternal age

Unfortunately, there is no cure for Lethal hydranencephaly-diaphragmatic hernia syndrome. Treatment is focused on managing the symptoms and providing supportive care. Medications may be used to help control seizures, manage pain, and reduce inflammation.