Late-onset isolated ACTH deficiency is a rare disorder characterized by a deficiency of the hormone adrenocorticotropic hormone (ACTH) in the body. It usually occurs in adults over the age of 40 and is caused by a mutation in the gene that codes for the ACTH receptor. Symptoms of this disorder include fatigue, weight loss, low blood pressure, and low cortisol levels. Treatment typically involves hormone replacement therapy with hydrocortisone or prednisone.

Symptoms of late-onset isolated ACTH deficiency can include fatigue, muscle weakness, weight loss, low blood pressure, low blood sugar, and low cortisol levels. Other symptoms may include depression, anxiety, irritability, and difficulty concentrating. In some cases, people may also experience joint pain, abdominal pain, and nausea.

The causes of late-onset isolated ACTH deficiency are not well understood. Possible causes include genetic mutations, autoimmune disorders, and certain medications. Other potential causes include infections, trauma, and tumors.

The primary treatment for late-onset isolated ACTH deficiency is hormone replacement therapy. This involves taking a synthetic form of cortisol, a hormone produced by the adrenal glands, to replace the cortisol that is not being produced. Other treatments may include lifestyle modifications such as stress management, dietary changes, and exercise. In some cases, medications such as hydrocortisone or prednisone may be prescribed to help manage symptoms. In severe cases, surgery may be necessary to remove the affected adrenal gland.

1. Age: Late-onset isolated ACTH deficiency is more common in adults over the age of 40.

2. Gender: Women are more likely to be affected than men.

3. Genetics: Certain genetic mutations have been linked to an increased risk of developing late-onset isolated ACTH deficiency.

4. Autoimmune disorders: People with autoimmune disorders such as Addison’s disease or type 1 diabetes are at an increased risk of developing late-onset isolated ACTH deficiency.

5. Certain medications: Certain medications, such as corticosteroids, can increase the risk of developing late-onset isolated ACTH deficiency.

Yes, there is a cure for late-onset isolated ACTH deficiency. Treatment typically involves taking a daily dose of hydrocortisone, a synthetic form of cortisol, to replace the missing cortisol. Other medications, such as fludrocortisone, may also be prescribed to help regulate the body's salt and water balance. In some cases, surgery may be recommended to remove the tumor causing the deficiency.