KLHL7-related cold-induced sweating-like syndrome (KLHL7-CSLS) is a rare genetic disorder caused by mutations in the KLHL7 gene. It is characterized by episodes of cold-induced sweating, which can be accompanied by shivering, paleness, and fatigue. The episodes can last for several hours and can be triggered by exposure to cold temperatures or stress.

The symptoms of KLHL7-related cold-induced sweating-like syndrome include:

-Cold sweats
-Excessive sweating
-Shivering
-Muscle cramps
-Fatigue
-Headache
-Nausea
-Dizziness
-Lightheadedness
-Palpitations
-Shortness of breath
-Chest pain
-Anxiety

The exact cause of KLHL7-related cold-induced sweating-like syndrome is unknown. However, it is believed to be caused by a mutation in the KLHL7 gene, which is responsible for producing a protein that helps regulate the body’s response to cold temperatures. This mutation may cause the body to overreact to cold temperatures, resulting in excessive sweating. Other possible causes include an autoimmune disorder, an infection, or an underlying medical condition.

1. Antidepressants: Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) are commonly used to treat the symptoms of KLHL7-related cold-induced sweating-like syndrome.

2. Anticonvulsants: Anticonvulsants such as gabapentin and pregabalin may be used to reduce the intensity of the sweating episodes.

3. Beta-blockers: Beta-blockers such as propranolol may be used to reduce the frequency and intensity of the sweating episodes.

4. Clonidine: Clonidine may be used to reduce the intensity of the sweating episodes.

5. Botulinum toxin injections: Botulinum toxin injections may be used to reduce the intensity of the sweating episodes.

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1. Genetic predisposition: People with a family history of KLHL7-related cold-induced sweating-like syndrome are at higher risk of developing the condition.

2. Age: The condition is more common in children and young adults.

3. Gender: Females are more likely to be affected than males.

4. Exposure to cold temperatures: People who are exposed to cold temperatures for extended periods of time are at higher risk of developing the condition.

5. Certain medications: Certain medications, such as beta-blockers, can increase the risk of developing the condition.

At this time, there is no known cure or medications for KLHL7-related cold-induced sweating-like syndrome. However, there are some treatments that may help to reduce the symptoms. These include avoiding cold temperatures, wearing layers of clothing, and using a humidifier to keep the air moist. Additionally, medications such as anticholinergics and tricyclic antidepressants may be prescribed to help reduce sweating.