Isolated splenic vein thrombosis (ISVT) is a rare condition in which a blood clot forms in the splenic vein, a large vein that carries blood from the spleen to the liver. ISVT can cause abdominal pain, nausea, and vomiting, and can lead to complications such as portal hypertension and splenic infarction. Treatment typically involves anticoagulant medications and, in some cases, surgery.

The most common symptom of isolated splenic vein thrombosis is abdominal pain. Other symptoms may include nausea, vomiting, fever, chills, and jaundice. In some cases, the patient may experience a feeling of fullness in the upper abdomen, or a feeling of pressure in the left upper quadrant. In more severe cases, the patient may experience shock, or even death.

The most common cause of isolated splenic vein thrombosis is pancreatitis. Other causes include trauma, abdominal surgery, malignancy, and hypercoagulable states. Other rare causes include infection, pregnancy, and systemic inflammatory diseases.

The main treatment for isolated splenic vein thrombosis is anticoagulation therapy, which involves taking medications such as warfarin or heparin to prevent further clotting. Other treatments may include thrombolytic therapy, which involves using medications to dissolve the clot, or surgical intervention to remove the clot. In some cases, a splenectomy (surgical removal of the spleen) may be necessary. In addition, lifestyle changes such as quitting smoking, maintaining a healthy weight, and exercising regularly can help reduce the risk of developing this condition.

1. Cirrhosis
2. Portal hypertension
3. Pancreatic cancer
4. Pancreatitis
5. Abdominal trauma
6. Hypercoagulable states
7. Pregnancy
8. Oral contraceptive use
9. Hyperlipidemia
10. Obesity
11. Smoking
12. Immobility
13. Intra-abdominal infection
14. Hyperhomocysteinemia
15. Paroxysmal nocturnal hemoglobinuria

The treatment for isolated splenic vein thrombosis is anticoagulation therapy with medications such as heparin or warfarin. In some cases, thrombolytic therapy may be used to dissolve the clot. In severe cases, surgery may be necessary to remove the clot.