Isolated generalized anhidrosis with normal sweat glands is a rare condition in which a person is unable to sweat normally, even though their sweat glands are normal. This condition is caused by a malfunction in the nervous system, which prevents the sweat glands from responding to signals from the brain to produce sweat. People with this condition may experience excessive heat intolerance, as well as an inability to regulate their body temperature.

The main symptom of isolated generalized anhidrosis with normal sweat glands is the inability to sweat normally. This condition can cause a person to feel overheated and uncomfortable in hot environments, and can lead to heat exhaustion or heat stroke. Other symptoms may include dry skin, itching, and a feeling of tightness in the skin.

The exact cause of isolated generalized anhidrosis with normal sweat glands is unknown. However, it is believed to be caused by a combination of genetic and environmental factors. Possible causes include autoimmune disorders, nerve damage, and certain medications.

1. Anticholinergic medications: These medications work by blocking the action of the neurotransmitter acetylcholine, which is responsible for triggering sweat production.

2. Botulinum toxin injections: Botulinum toxin injections can be used to temporarily block the sweat glands and reduce sweating.

3. Sympathectomy: This is a surgical procedure that involves cutting or destroying the nerves that control sweat production.

4. Topical creams: Topical creams containing aluminum chloride or glycopyrrolate can be used to reduce sweating.

5. Cooling garments: Cooling garments, such as cooling vests, can be used to reduce sweating.

6. Stress management: Stress management techniques, such as relaxation techniques, can help reduce sweating.

1. Genetic predisposition
2. Autoimmune disorders
3. Certain medications
4. Exposure to environmental toxins
5. Certain infections
6. Trauma or injury
7. Endocrine disorders
8. Certain neurological conditions
9. Radiation therapy
10. Heat intolerance

At this time, there is no known cure for isolated generalized anhidrosis with normal sweat glands. However, there are medications that can help to reduce the symptoms of anhidrosis, such as anticholinergic medications, topical creams, and oral medications. Additionally, lifestyle modifications such as avoiding hot environments, wearing loose-fitting clothing, and using cooling devices can help to reduce the symptoms of anhidrosis.