Infantile-onset generalized dyskinesia with orofacial involvement (IOGD-OF) is a rare neurological disorder characterized by involuntary movements of the face, tongue, and jaw. Symptoms typically begin in infancy and may include facial grimacing, tongue thrusting, and jaw opening and closing. Other symptoms may include drooling, difficulty speaking, and difficulty eating. The cause of IOGD-OF is unknown, but it is thought to be related to a genetic mutation. Treatment is symptomatic and may include medications, physical therapy, and speech therapy.

The symptoms of Infantile-onset generalized dyskinesia with orofacial involvement can vary from person to person, but may include:

-Involuntary movements of the face, mouth, and tongue
-Involuntary movements of the arms and legs
-Difficulty speaking
-Difficulty swallowing
-Drooling
-Grimacing
-Abnormal posture
-Difficulty walking
-Difficulty with fine motor skills
-Difficulty with coordination
-Muscle stiffness
-Fatigue
-Seizures

The exact cause of Infantile-onset generalized dyskinesia with orofacial involvement is unknown. However, it is believed to be caused by a combination of genetic and environmental factors. Mutations in the SLC2A1 gene have been identified as a cause of this condition. Other potential causes include exposure to certain toxins, infections, and metabolic disorders.

1. Medication: Anticholinergic medications, such as trihexyphenidyl, may be used to reduce involuntary movements.

2. Physical therapy: Physical therapy can help improve muscle strength and coordination.

3. Surgery: Surgery may be recommended in some cases to reduce the severity of the symptoms.

4. Botulinum toxin injections: Botulinum toxin injections may be used to reduce muscle spasms in the face and mouth.

5. Deep brain stimulation: Deep brain stimulation is a surgical procedure that involves implanting electrodes in the brain to reduce involuntary movements.

6. Dietary changes: Dietary changes, such as avoiding certain foods, may help reduce symptoms.

1. Genetic mutations in the SLC2A1 gene
2. Mutations in the PNKP gene
3. Mutations in the PANK2 gene
4. Mutations in the PLA2G6 gene
5. Mutations in the ATP13A2 gene
6. Mutations in the CACNA1A gene
7. Mutations in the ATP1A3 gene
8. Mutations in the PRRT2 gene
9. Mutations in the SLC6A5 gene
10. Mutations in the SLC6A8 gene
11. Mutations in the SLC6A19 gene
12. Mutations in the SLC6A20 gene
13. Mutations in the SLC6A18 gene
14. Mutations in the SLC6A17 gene
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There is no cure for Infantile-onset generalized dyskinesia with orofacial involvement, but medications can be used to help manage the symptoms. These medications include anticholinergics, dopamine agonists, and benzodiazepines. Additionally, physical and occupational therapy can help improve motor skills and reduce the severity of symptoms.