Indomethacin embryofetopathy is a rare condition caused by the use of the drug indomethacin during pregnancy. It is characterized by a variety of birth defects, including facial malformations, limb defects, and heart and kidney problems. It is believed to be caused by the drug's interference with normal fetal development.

The symptoms of Indomethacin embryofetopathy vary depending on the severity of the condition. Common symptoms include:

• Low birth weight

• Small head circumference
• Abnormal facial features
• Cleft lip or palate
• Abnormalities of the heart, lungs, kidneys, and other organs
• Abnormalities of the skeleton
• Intellectual disability
• Seizures
• Vision and hearing problems
• Feeding difficulties
• Poor growth
• Abnormalities of the genitalia

Indomethacin embryofetopathy is a rare condition caused by the use of the drug indomethacin during pregnancy. It is thought to be caused by the drug's ability to inhibit prostaglandin synthesis, which is necessary for normal fetal development. Other potential causes include genetic factors, maternal health conditions, and environmental exposures.

The treatment for Indomethacin embryofetopathy is supportive care. This includes monitoring the baby's growth and development, providing nutrition and hydration, and providing physical and occupational therapy as needed. In some cases, surgery may be necessary to correct any physical deformities or abnormalities. In addition, genetic counseling may be recommended to help families understand the risks of recurrence in future pregnancies.

1. Maternal use of indomethacin during the first trimester of pregnancy.
2. Maternal use of high doses of indomethacin during pregnancy.
3. Maternal use of indomethacin for prolonged periods of time during pregnancy.
4. Maternal use of indomethacin in combination with other medications during pregnancy.
5. Maternal use of indomethacin in combination with other drugs that may increase the risk of embryofetopathy.
6. Maternal use of indomethacin in combination with other drugs that may decrease the effectiveness of indomethacin.
7. Maternal use of indomethacin in combination with other drugs that may increase the risk of adverse effects.
8. Maternal use of indomethacin in combination

At this time, there is no known cure or medications for Indomethacin embryofetopathy. Treatment is focused on managing the symptoms and complications associated with the condition. This may include physical therapy, occupational therapy, speech therapy, and other supportive therapies.