IgG4-related mesenteritis is a rare inflammatory disorder that affects the mesentery, a thin membrane that connects the intestines to the abdominal wall. It is characterized by an accumulation of IgG4-positive plasma cells and lymphocytes in the mesentery, which can lead to fibrosis and thickening of the tissue. Symptoms may include abdominal pain, nausea, vomiting, and weight loss. Treatment typically involves corticosteroids and other immunosuppressive medications.

The most common symptoms of IgG4-related mesenteritis include abdominal pain, nausea, vomiting, diarrhea, weight loss, and fever. Other symptoms may include fatigue, joint pain, and swelling of the abdomen. In some cases, patients may also experience jaundice, anemia, and an Enlarged liver or spleen.

The exact cause of IgG4-related mesenteritis is unknown. However, it is believed to be an autoimmune disorder, meaning that the body's immune system mistakenly attacks healthy tissue. It is also thought to be related to other autoimmune disorders, such as Hashimoto's thyroiditis, Sjogren's syndrome, and inflammatory bowel disease.

The main treatment for IgG4-related mesenteritis is corticosteroid therapy. This is usually given in the form of oral prednisone or intravenous methylprednisolone. Other treatments may include immunosuppressants such as azathioprine or methotrexate, or biologic agents such as rituximab or tocilizumab. In some cases, surgery may be necessary to remove affected tissue.

1. Age: IgG4-related mesenteritis is more common in middle-aged and elderly individuals.

2. Gender: Men are more likely to develop IgG4-related mesenteritis than women.

3. Genetics: Certain genetic factors may increase the risk of developing IgG4-related mesenteritis.

4. Autoimmune diseases: People with autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and Sjogren’s syndrome are more likely to develop IgG4-related mesenteritis.

5. Medications: Certain medications, such as corticosteroids, may increase the risk of developing IgG4-related mesenteritis.

Yes, there are treatments available for IgG4-related mesenteritis. Treatment typically involves a combination of medications, such as corticosteroids, immunosuppressants, and biologics. In some cases, surgery may be necessary to remove affected tissue.