Huntington disease-like 2 (HDL2) is a rare, inherited neurological disorder that is similar to Huntington disease (HD). HDL2 is caused by a mutation in the same gene that causes HD, but the symptoms of HDL2 are usually milder and progress more slowly than those of HD. Symptoms of HDL2 may include difficulty with movement, balance, and coordination; cognitive decline; and psychiatric symptoms such as depression and anxiety.

1. Uncontrolled movements, such as jerking, twitching, or writhing
2. Loss of coordination
3. Cognitive decline, including difficulty with problem solving, memory, and judgment
4. Changes in behavior, such as depression, irritability, and impulsiveness
5. Difficulty speaking or swallowing
6. Weight loss
7. Difficulty walking or performing other physical tasks
8. Loss of facial expression

1. Genetic mutation: Huntington disease is caused by a mutation in the huntingtin gene. This gene produces a protein called huntingtin, which is essential for normal brain development.

2. Environmental factors: Exposure to certain environmental toxins, such as pesticides, may increase the risk of developing Huntington disease. Additionally, certain medications, such as antipsychotics, may increase the risk of developing the disease.

1. Medication: Medications can help manage the symptoms of Huntington disease-like 2, including chorea, depression, anxiety, and cognitive impairment. These medications may include antipsychotics, antidepressants, anticonvulsants, and dopamine agonists.

2. Physical Therapy: Physical therapy can help improve balance, coordination, and mobility. It can also help reduce the risk of falls.

3. Occupational Therapy: Occupational therapy can help improve daily living skills, such as dressing, bathing, and eating.

4. Speech Therapy: Speech therapy can help improve communication skills.

5. Nutritional Therapy: Nutritional therapy can help improve overall health and reduce the risk of malnutrition.

6. Genetic Counseling: Genetic counseling can help individuals and families understand the risks associated with Huntington disease-like 2 and make informed

1. Family history of Huntington disease-like 2
2. Age (most commonly diagnosed in people over 50)
3. Genetic mutation in the JPH3 gene
4. Exposure to certain environmental toxins
5. Certain medications
6. Alcohol and tobacco use
7. Head trauma

At this time, there is no cure for Huntington disease-like 2. However, medications can be used to help manage the symptoms of the disease. These medications may include antipsychotics, antidepressants, anticonvulsants, and other medications to help with movement, mood, and cognitive problems. Additionally, physical, occupational, and speech therapy can help improve quality of life.