Hereditary sensory and autonomic neuropathy with deafness and global delay (HSANDDGD) is a rare genetic disorder characterized by progressive hearing loss, sensory neuropathy, and global developmental delay. It is caused by mutations in the GJB2 gene, which is responsible for the production of a protein called connexin 26. This protein is important for the proper functioning of the inner ear and the autonomic nervous system. Symptoms of HSANDDGD include hearing loss, balance problems, poor coordination, and difficulty with speech and language development. Other symptoms may include seizures, vision problems, and intellectual disability. Treatment for HSANDDGD is supportive and may include hearing aids, physical therapy, and speech therapy.

Symptoms of Hereditary Sensory and Autonomic Neuropathy with Deafness and Global Delay (HSANDGD) can vary from person to person, but may include:

- Hearing loss
- Delayed development of motor skills
- Poor coordination
- Muscle weakness
- Balance problems
- Abnormal gait
- Sensory loss in the hands and feet
- Loss of sensation in the face
- Abnormal sweating
- Abnormal pupil responses
- Abnormal reflexes
- Abnormal blood pressure responses
- Abnormal heart rate responses
- Abnormal digestive system responses
- Abnormal bladder and bowel control
- Abnormal temperature regulation
- Abnormal breathing responses
- Abnormal sleep patterns
- Seizures
- Cognitive impairment

Hereditary sensory and autonomic neuropathy with deafness and global delay (HSANDDG) is a rare genetic disorder caused by mutations in the GJB2 gene. This gene is responsible for producing a protein called connexin 26, which is essential for the proper functioning of the auditory and autonomic nervous systems. Mutations in this gene can lead to a variety of symptoms, including hearing loss, balance problems, and delayed development. Other causes of HSANDDG may include mutations in other genes, such as GJB6, GJB3, and GJB4, as well as environmental factors.

1. Physical therapy: Physical therapy can help improve strength, coordination, and balance.

2. Occupational therapy: Occupational therapy can help with activities of daily living, such as dressing, eating, and bathing.

3. Speech therapy: Speech therapy can help with communication and swallowing difficulties.

4. Medications: Medications can help manage pain, seizures, and other symptoms.

5. Assistive devices: Assistive devices, such as hearing aids, wheelchairs, and walkers, can help with mobility.

6. Surgery: Surgery may be necessary to correct certain physical deformities.

7. Genetic counseling: Genetic counseling can help families understand the condition and its inheritance.

1. Family history of Hereditary Sensory and Autonomic Neuropathy with Deafness and Global Delay (HSANDGD).
2. Genetic mutations in the GJB2 gene.
3. Exposure to certain environmental toxins.
4. Low birth weight.
5. Premature birth.
6. Maternal diabetes.
7. Maternal smoking during pregnancy.
8. Maternal alcohol consumption during pregnancy.
9. Maternal drug use during pregnancy.
10. Maternal nutritional deficiencies during pregnancy.

There is no cure for Hereditary Sensory and Autonomic Neuropathy with Deafness and Global Delay (HSANDGD). Treatment focuses on managing the symptoms and preventing further complications. Medications may be prescribed to help manage pain, reduce inflammation, and improve muscle strength. Physical and occupational therapy can help improve motor skills and coordination. Speech therapy may be recommended to help improve communication skills. Assistive devices such as hearing aids and wheelchairs may be necessary to help with mobility and communication.