Hereditary mixed polyposis syndrome (HMPS) is a rare inherited disorder characterized by the presence of multiple polyps in the gastrointestinal tract. These polyps can be of different types, including adenomatous, hyperplastic, and inflammatory. HMPS is caused by a mutation in the APC gene, which is responsible for controlling cell growth and division. Symptoms of HMPS include abdominal pain, rectal bleeding, and changes in bowel habits. If left untreated, HMPS can lead to colorectal cancer. Treatment typically involves surgery to remove the polyps and regular colonoscopies to monitor for new polyps.

The most common symptoms of Hereditary mixed polyposis syndrome include:

-Abdominal pain
-Rectal bleeding
-Diarrhea
-Weight loss
-Fatigue
-Anemia
-Iron deficiency
-Rectal prolapse
-Frequent bowel movements
-Rectal pain
-Rectal itching
-Rectal discharge
-Rectal blockage
-Rectal ulcers
-Rectal strictures
-Rectal fistulas

Hereditary mixed polyposis syndrome (HMPS) is a rare inherited disorder caused by a mutation in the MYH gene. This gene is responsible for producing a protein that helps repair damaged DNA. When the MYH gene is mutated, the protein it produces is not able to repair damaged DNA, leading to the development of multiple polyps in the colon. HMPS is inherited in an autosomal recessive pattern, meaning that both copies of the gene must be mutated for a person to be affected by the disorder.

The main treatment for Hereditary mixed polyposis syndrome is surgery. This may involve removing the entire colon and rectum (colectomy) or removing only the affected parts of the colon (polypectomy). Other treatments may include medications to reduce inflammation, antibiotics to treat infections, and lifestyle changes to reduce the risk of developing polyps. In some cases, genetic counseling may be recommended to help individuals understand their risk of passing the condition on to their children.

1. Family history of Hereditary mixed polyposis syndrome
2. Having a mutation in the BMPR1A, SMAD4, or PTEN gene
3. Having a personal history of colorectal polyps
4. Having a personal history of colorectal cancer
5. Having a personal history of other cancers, such as endometrial, ovarian, gastric, or pancreatic cancer
6. Being of Ashkenazi Jewish descent
7. Being of African American descent

There is no cure for Hereditary mixed polyposis syndrome, but medications can be used to help manage symptoms. These medications may include anti-inflammatory drugs, antibiotics, and anticoagulants. Surgery may also be necessary to remove polyps or to treat complications.