Hereditary angioedema type 2 (HAE type 2) is a rare, inherited disorder that causes episodes of swelling in the face, extremities, gastrointestinal tract, and airway. It is caused by a deficiency of the C1-esterase inhibitor protein, which is responsible for regulating the activity of certain enzymes in the body. Symptoms of HAE type 2 can include swelling of the face, tongue, and throat, abdominal pain, nausea, vomiting, and difficulty breathing. Treatment for HAE type 2 typically involves the use of medications to reduce the frequency and severity of attacks.

The symptoms of Hereditary angioedema type 2 (HAE2) can vary from person to person, but typically include:

- Swelling of the face, tongue, hands, feet, and/or abdomen

- Abdominal pain

- Nausea and vomiting

- Difficulty breathing

- Hives or itchy skin

- Fatigue

- Anxiety or depression

- Joint pain

- Fever

- Swollen lymph nodes

Hereditary angioedema type 2 (HAE type 2) is caused by a mutation in the SERPING1 gene, which is responsible for producing the C1-esterase inhibitor (C1-INH) protein. This protein helps regulate the activity of certain enzymes in the body, including those involved in the immune system. Without enough C1-INH, the body is unable to control the activity of these enzymes, leading to an increase in inflammation and swelling.

The main treatments for Hereditary angioedema type 2 are:

1. Antifibrinolytic drugs such as tranexamic acid, epsilon aminocaproic acid, and aprotinin. These drugs help to reduce the breakdown of blood clots and can help to reduce the severity of attacks.

2. C1-inhibitor replacement therapy. This involves replacing the missing or deficient C1-inhibitor protein with a synthetic version. This can help to reduce the frequency and severity of attacks.

3. Corticosteroids. These drugs can help to reduce inflammation and can be used to treat acute attacks.

4. Antihistamines. These drugs can help to reduce the symptoms of an attack.

5. Immunomodulators. These drugs can help

1. Family history of Hereditary angioedema type 2
2. Age (onset typically occurs in childhood or adolescence)
3. Gender (more common in males)
4. Genetic mutation in the SERPING1 gene
5. Exposure to certain triggers such as stress, certain medications, or certain foods

Yes, there are medications available to treat Hereditary Angioedema Type 2. These include C1-inhibitor (C1-INH) replacement therapy, antifibrinolytic agents, and kallikrein inhibitors. Additionally, lifestyle modifications such as avoiding triggers, eating a healthy diet, and getting regular exercise can help reduce symptoms.