Heart-hand syndrome type 3 (HHS3) is a rare genetic disorder characterized by congenital heart defects, hand malformations, and intellectual disability. It is caused by a mutation in the TBX5 gene, which is responsible for the development of the heart and hands. Symptoms of HHS3 include heart defects such as atrial septal defect, ventricular septal defect, and patent ductus arteriosus, as well as hand malformations such as syndactyly, brachydactyly, and clinodactyly. People with HHS3 may also have developmental delays, learning disabilities, and behavioral problems. Treatment for HHS3 typically involves surgery to repair the heart defects and physical therapy to improve hand function.

The symptoms of Heart-hand Syndrome type 3 vary from person to person, but may include:

-Heart defects, such as atrial septal defect, ventricular septal defect, and patent ductus arteriosus
-Hand and foot abnormalities, such as syndactyly (webbed fingers and toes), polydactyly (extra fingers and toes), and brachydactyly (short fingers and toes)
-Cleft lip and/or palate
-Cognitive and developmental delays
-Hearing loss
-Vision problems
-Kidney abnormalities
-Gastrointestinal problems
-Feeding difficulties
-Hypotonia (low muscle tone)
-Scoliosis (curvature of the spine)
-Joint contractures (Stiffness of the joints)
-Skin

Heart-hand syndrome type 3 is caused by a mutation in the TBX5 gene. This gene is responsible for the development of the heart and hands during embryonic development. Mutations in this gene can lead to a variety of heart and hand abnormalities, including heart-hand syndrome type 3.

The treatments for Heart-hand syndrome type 3 vary depending on the severity of the condition and the individual's symptoms. Generally, treatment may include physical therapy, occupational therapy, speech therapy, and medications to help manage symptoms. Surgery may be recommended in some cases to correct any physical deformities or to improve the function of the affected organs. In addition, genetic counseling may be recommended to help individuals and families understand the condition and its implications.

1. Family history of Heart-hand syndrome type 3
2. Maternal diabetes
3. Maternal obesity
4. Maternal smoking
5. Maternal alcohol consumption
6. Maternal age over 35
7. Maternal use of certain medications
8. Advanced paternal age
9. Advanced maternal age
10. Low birth weight

At this time, there is no known cure for Heart-hand syndrome type 3. However, there are medications that can be used to manage the symptoms of the condition. These include medications to control seizures, muscle spasms, and other symptoms. Additionally, physical and occupational therapy can help to improve motor skills and coordination.