Heart-hand syndrome type 2 (also known as Holt-Oram syndrome) is a rare genetic disorder that affects the development of the heart and upper limbs. It is caused by a mutation in the TBX5 gene, which is responsible for the development of the heart and upper limbs. Symptoms of the disorder include abnormalities of the heart, such as atrial and ventricular septal defects, as well as abnormalities of the upper limbs, such as thumb and radial ray defects.

The symptoms of Heart-hand syndrome type 2 vary from person to person, but may include:

-Heart defects, such as atrial septal defect, ventricular septal defect, and patent ductus arteriosus
-Abnormalities of the hands and feet, such as syndactyly (webbed fingers and toes), polydactyly (extra fingers and toes), and brachydactyly (short fingers and toes)
-Cleft lip and/or palate
-Abnormalities of the eyes, such as coloboma (a gap in the iris)
-Abnormalities of the ears, such as preauricular pits (small pits in front of the ears)
-Abnormalities of the skull, such as craniosynostosis (premature fusion of the

Heart-hand syndrome type 2 is caused by a mutation in the TBX5 gene. This gene is responsible for the development of the heart and hands during embryonic development. Mutations in this gene can lead to a variety of heart and hand abnormalities, including heart-hand syndrome type 2.

Treatment for Heart-hand syndrome type 2 typically involves a combination of medications, physical therapy, and lifestyle changes. Medications may include beta-blockers, ACE inhibitors, and diuretics to help control blood pressure and reduce the risk of stroke. Physical therapy can help improve strength and coordination, while lifestyle changes such as quitting smoking, eating a healthy diet, and exercising regularly can help reduce the risk of complications. Surgery may be recommended in some cases to repair or replace damaged heart valves.

1. Family history of Heart-hand syndrome type 2
2. Maternal diabetes
3. Maternal obesity
4. Maternal smoking
5. Maternal alcohol consumption
6. Maternal age over 35
7. Maternal use of certain medications
8. Advanced paternal age
9. Low birth weight
10. Premature birth

At this time, there is no known cure for Heart-hand syndrome type 2. However, there are medications that can be used to manage the symptoms of the condition. These include medications to control seizures, muscle spasms, and other symptoms. Additionally, physical and occupational therapy can help improve motor skills and coordination.