About Gyrate atrophy of choroid and retina

What is Gyrate atrophy of choroid and retina?

Gyrate atrophy of choroid and retina is a rare, inherited disorder that affects the eyes. It is caused by a deficiency of the enzyme ornithine aminotransferase (OAT). This enzyme is necessary for the metabolism of the amino acid ornithine. Without it, ornithine accumulates in the body, leading to a buildup of toxic metabolites in the eyes. Symptoms of gyrate atrophy include progressive vision loss, night blindness, and a decrease in color vision. Treatment includes dietary changes and supplementation with vitamins and minerals.

What are the symptoms of Gyrate atrophy of choroid and retina?

The symptoms of Gyrate Atrophy of choroid and retina include:

-Decreased vision

-Night blindness

-Decreased color vision

-Decreased peripheral vision

-Blurred vision

-Sensitivity to light

-Decreased visual acuity

-Abnormal eye movements

-Abnormal eye alignment

-Cataracts

-Retinal detachment

-Retinal degeneration

-Retinal thinning

-Macular degeneration

-Retinal pigmentary changes

-Choroidal neovascularization

What are the causes of Gyrate atrophy of choroid and retina?

Gyrate atrophy of the choroid and retina is caused by a genetic mutation in the ornithine aminotransferase (OAT) gene. This gene mutation leads to an accumulation of the amino acid ornithine in the body, which can cause damage to the choroid and retina. Other causes of gyrate atrophy include a deficiency in vitamin A, a lack of dietary protein, and a deficiency in the enzyme arginase.

What are the treatments for Gyrate atrophy of choroid and retina?

1. Vitamin A supplementation: Vitamin A supplementation is the mainstay of treatment for gyrate atrophy of the choroid and retina. Vitamin A is essential for the normal functioning of the retina and choroid, and supplementation can help slow the progression of the disease.

2. Low protein diet: A low protein diet is recommended to reduce the amount of ornithine in the body. This can help reduce the amount of toxic metabolites that accumulate in the retina and choroid.

3. Surgery: Surgery may be recommended to reduce the pressure in the eye caused by the accumulation of fluid. This can help reduce the risk of vision loss.

4. Gene therapy: Gene therapy is a promising new treatment for gyrate atrophy of the choroid and retina. This involves introducing a healthy gene into the cells of the

What are the risk factors for Gyrate atrophy of choroid and retina?

1. Inherited genetic mutation in the ornithine aminotransferase (OAT) gene.
2. Deficiency of ornithine aminotransferase (OAT) enzyme.
3. High levels of ornithine in the blood.
4. Male gender.
5. Advanced age.
6. Family history of the condition.
7. Certain ethnic backgrounds, such as Ashkenazi Jews.

Is there a cure/medications for Gyrate atrophy of choroid and retina?

Yes, there is a medication called cevimeline (Evoxac) that can help slow the progression of Gyrate atrophy of choroid and retina. It is a cholinergic agonist that helps increase the production of aqueous humor in the eye, which can help reduce the swelling and pressure in the eye. Additionally, dietary modifications such as a low-arginine diet can help reduce the symptoms of Gyrate atrophy.