Greig Cephalopolysyndactyly Syndrome (GCPS) is a rare genetic disorder characterized by craniofacial abnormalities, skeletal malformations, and intellectual disability. It is caused by a mutation in the GLI3 gene. Symptoms may include craniofacial abnormalities such as a large head, wide-set eyes, a prominent forehead, and a cleft lip and/or palate. Skeletal malformations may include syndactyly (fused fingers and/or toes), polydactyly (extra fingers and/or toes), and scoliosis. Intellectual disability is common in individuals with GCPS.

The most common symptoms of Greig Cephalopolysyndactyly Syndrome (GCPS) include:

- Craniofacial abnormalities, such as a wide forehead, a prominent forehead, a flat midface, a wide nasal bridge, and a small lower jaw
- Syndactyly (webbed fingers and/or toes)
- Intellectual disability
- Seizures
- Abnormalities of the eyes, such as strabismus (crossed eyes) and/or cataracts
- Abnormalities of the ears, such as hearing loss
- Abnormalities of the heart, such as a hole in the heart
- Abnormalities of the kidneys, such as cysts or malformations
- Abnormalities of the spine, such as scoliosis
- Abnormalities of the

Greig Cephalopolysyndactyly Syndrome (GCPS) is a rare genetic disorder caused by a mutation in the GLI3 gene. This gene is responsible for the development of the skull, face, hands, and feet. The exact cause of the mutation is unknown, but it is believed to be inherited in an autosomal dominant pattern.

The treatments for Greig Cephalopolysyndactyly Syndrome (GCPS) vary depending on the severity of the condition and the individual's specific needs. Generally, treatment may include:

1. Surgery: Surgery is often used to correct physical abnormalities associated with GCPS, such as webbed fingers and toes, extra digits, and facial deformities.

2. Physical therapy: Physical therapy can help improve strength, flexibility, and range of motion in affected areas.

3. Occupational therapy: Occupational therapy can help individuals with GCPS learn how to perform daily activities and develop skills for independent living.

4. Speech therapy: Speech therapy can help individuals with GCPS improve their communication skills.

5. Genetic counseling: Genetic counseling can help individuals and families understand the condition and its implications.

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The primary risk factor for Greig Cephalopolysyndactyly Syndrome is a family history of the disorder. Other risk factors include advanced maternal age, a history of consanguinity (marriage between close relatives), and a history of genetic mutations.

At this time, there is no cure for Greig Cephalopolysyndactyly Syndrome. However, there are medications and treatments available to help manage the symptoms. These include physical therapy, occupational therapy, speech therapy, orthopedic surgery, and medications to help with pain, seizures, and other symptoms.