Grange syndrome is a rare genetic disorder characterized by a combination of physical and mental disabilities. It is caused by a mutation in the gene that codes for the enzyme dihydropyrimidine dehydrogenase (DPD). Symptoms of Grange syndrome include intellectual disability, seizures, delayed development, and facial abnormalities.

The symptoms of Grange syndrome vary from person to person, but may include:

-Developmental delays
-Intellectual disability
-Seizures
-Feeding difficulties
-Gastrointestinal problems
-Growth delays
-Facial abnormalities
-Hearing loss
-Heart defects
-Kidney abnormalities
-Skeletal abnormalities
-Skin abnormalities
-Vision problems

Grange syndrome is a rare genetic disorder caused by a mutation in the GAN gene. This gene is responsible for producing the protein ganglioside, which is important for the development of the nervous system. The exact cause of the mutation is unknown, but it is believed to be inherited in an autosomal recessive pattern.

The primary treatment for Grange syndrome is to manage the symptoms. This may include physical therapy, occupational therapy, speech therapy, and medications to help with pain, muscle spasms, and seizures. Surgery may be recommended in some cases to correct any underlying structural issues. Other treatments may include dietary changes, supplements, and lifestyle modifications.

1. Genetic predisposition: Grange syndrome is caused by a mutation in the gene that codes for the enzyme dihydropyrimidine dehydrogenase (DPD).

2. Age: Grange syndrome is more common in children and young adults.

3. Gender: Grange syndrome is more common in males than females.

4. Ethnicity: Grange syndrome is more common in people of Asian descent.

5. Exposure to certain medications: Certain medications, such as 5-fluorouracil, can increase the risk of developing Grange syndrome.

At this time, there is no known cure for Grange Syndrome. Treatment focuses on managing the symptoms and includes medications to reduce inflammation, physical therapy, and occupational therapy.