About Glucose-Galactose Malabsorption

What is Glucose-Galactose Malabsorption?

Glucose-Galactose Malabsorption is a rare inherited disorder in which the body is unable to absorb glucose and galactose, two simple sugars found in many foods. People with this disorder experience severe diarrhea, abdominal pain, and bloating after eating foods that contain these sugars. Treatment typically involves avoiding foods that contain glucose and galactose, as well as taking medications to help manage symptoms.

What are the symptoms of Glucose-Galactose Malabsorption?

The symptoms of Glucose-Galactose Malabsorption include:

-Diarrhea

-Abdominal cramps

-Bloating

-Gas

-Nausea

-Vomiting

-Weight loss

-Dehydration

-Electrolyte imbalances

-Fatigue

-Lethargy

-Poor growth in infants and children

What are the causes of Glucose-Galactose Malabsorption?

Glucose-Galactose Malabsorption is caused by a genetic mutation that affects the ability of the small intestine to absorb glucose and galactose. This mutation affects the activity of the enzyme, glucose-galactose transporter, which is responsible for transporting glucose and galactose from the small intestine into the bloodstream. Without this enzyme, glucose and galactose are not absorbed properly, leading to the symptoms of Glucose-Galactose Malabsorption.

What are the treatments for Glucose-Galactose Malabsorption?

1. Dietary modifications: The primary treatment for glucose-galactose malabsorption is to avoid foods that contain glucose-galactose, such as milk, yogurt, ice cream, and other dairy products. Other foods that contain glucose-galactose, such as certain fruits, vegetables, and grains, should also be avoided.

2. Lactose-free formula: If dietary modifications are not enough to manage symptoms, a lactose-free formula may be recommended. This formula is made with a combination of glucose and fructose, which can be absorbed by the body without the need for lactase.

3. Medications: In some cases, medications may be prescribed to help manage symptoms. These medications may include antibiotics, probiotics, or other medications that help to break down the glucose-galactose molecules.

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What are the risk factors for Glucose-Galactose Malabsorption?

1. Premature birth
2. Genetic mutation
3. Low levels of lactase enzyme
4. Intestinal damage or disease
5. Certain medications
6. Surgery on the small intestine
7. Radiation therapy to the abdomen
8. Infections of the small intestine

Is there a cure/medications for Glucose-Galactose Malabsorption?

Yes, there is a cure for Glucose-Galactose Malabsorption. The main treatment is to avoid foods that contain glucose-galactose, such as milk, yogurt, and ice cream. Other treatments include taking medications to help the body absorb glucose-galactose, such as lactase enzyme supplements, and taking probiotics to help restore the balance of bacteria in the gut.