About Gigantism and Acromegaly

What is Gigantism and Acromegaly?

Gigantism is a condition caused by an excess of growth hormone during childhood, resulting in an abnormally tall stature. Acromegaly is a condition caused by an excess of growth hormone in adults, resulting in an abnormal enlargement of the hands, feet, and face.

What are the symptoms of Gigantism and Acromegaly?

Gigantism:
-Excessive growth of the hands, feet, and face
-Enlarged jaw
-Coarse facial features
-Enlarged tongue
-Deepened voice
-Excessive sweating
-Headaches
-High blood pressure
-Enlarged organs
-Delayed puberty

Acromegaly:
-Enlarged hands, feet, and face
-Coarse facial features
-Enlarged tongue
-Deepened voice
-Excessive sweating
-Headaches
-High blood pressure
-Enlarged organs
-Enlarged heart
-Enlarged liver
-Enlarged kidneys
-Joint pain
-Fatigue
-Impaired vision
-Enlarged pituitary gland
-Enlarged thyroid gland
-Enlarged

What are the causes of Gigantism and Acromegaly?

Gigantism is caused by an excess of growth hormone (GH) during childhood, usually due to a tumor on the pituitary gland.

Acromegaly is caused by an excess of growth hormone (GH) in adulthood, usually due to a tumor on the pituitary gland. It can also be caused by tumors in other parts of the body that produce GH or other hormones that stimulate GH production.

What are the treatments for Gigantism and Acromegaly?

Gigantism:

The primary treatment for gigantism is surgery to remove the tumor that is causing the condition. In some cases, radiation therapy or chemotherapy may be used to shrink the tumor. In some cases, medications such as somatostatin analogs or dopamine agonists may be used to reduce the production of growth hormone.

Acromegaly:

The primary treatment for acromegaly is surgery to remove the tumor that is causing the condition. In some cases, radiation therapy or chemotherapy may be used to shrink the tumor. In some cases, medications such as somatostatin analogs or dopamine agonists may be used to reduce the production of growth hormone. In addition, medications such as octreotide or pegvisomant may be used to block the action of growth hormone.

What are the risk factors for Gigantism and Acromegaly?

Gigantism:

1. Pituitary adenoma: A benign tumor of the pituitary gland that produces too much growth hormone.

2. McCune-Albright Syndrome: A rare genetic disorder that causes abnormal growth hormone production.

3. Familial Gigantism: A rare genetic disorder that causes excessive growth hormone production.

Acromegaly:

1. Pituitary adenoma: A benign tumor of the pituitary gland that produces too much growth hormone.

2. Carcinoid Syndrome: A rare disorder caused by tumors in the digestive system that produce too much growth hormone.

3. Multiple Endocrine Neoplasia Type 1 (MEN1): A rare genetic disorder that causes tumors in the endocrine system, leading to excessive growth hormone production.

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Is there a cure/medications for Gigantism and Acromegaly?

Yes, there are treatments available for both Gigantism and Acromegaly. For Gigantism, the primary treatment is surgery to remove the tumor that is causing the overproduction of growth hormone. Medications such as somatostatin analogs, dopamine agonists, and growth hormone receptor antagonists may also be used to reduce the production of growth hormone. For Acromegaly, the primary treatment is surgery to remove the tumor that is causing the overproduction of growth hormone. Medications such as somatostatin analogs, dopamine agonists, and growth hormone receptor antagonists may also be used to reduce the production of growth hormone. Radiation therapy may also be used to reduce the size of the tumor. In some cases, medications such as octreotide and pegvisomant may be used to reduce the levels of growth hormone in the body.