Generalized Arterial Calcification of Infancy (GACI) is a rare genetic disorder that affects the arteries of infants. It is characterized by the abnormal accumulation of calcium in the walls of the arteries, which can lead to narrowing of the arteries and decreased blood flow. GACI can cause a variety of symptoms, including heart failure, stroke, and kidney failure. Treatment typically involves medications to reduce calcium levels and lifestyle modifications to reduce the risk of complications.

The symptoms of Generalized Arterial Calcification of Infancy (GACI) vary depending on the severity of the condition. Common symptoms include:

- Poor growth
- Abnormal heart rhythms
- High blood pressure
- Abnormal calcium levels in the blood
- Abnormal calcium levels in the urine
- Abnormal calcium levels in the bones
- Abnormal calcium levels in the soft tissues
- Abnormal calcium levels in the skin
- Abnormal calcium levels in the eyes
- Abnormal calcium levels in the kidneys
- Abnormal calcium levels in the liver
- Abnormal calcium levels in the pancreas
- Abnormal calcium levels in the brain
- Abnormal calcium levels in the muscles
- Abnormal calcium levels in the joints
- Abnormal calcium levels in the blood vessels
- Abnormal calcium

The exact cause of Generalized Arterial Calcification of Infancy (GACI) is unknown. However, it is believed to be caused by a genetic mutation that affects the body’s ability to regulate calcium levels in the blood. Other possible causes include an underlying metabolic disorder, a deficiency in certain vitamins or minerals, or an autoimmune disorder.

The primary treatment for Generalized Arterial Calcification of Infancy (GACI) is supportive care. This includes monitoring of vital signs, nutrition, hydration, and electrolyte balance. Other treatments may include medications to reduce inflammation, improve circulation, and reduce calcium levels in the blood. In some cases, surgery may be necessary to remove calcified arteries or to repair damaged vessels. In severe cases, dialysis may be necessary to remove excess calcium from the blood.

1. Prematurity
2. Low birth weight
3. Male gender
4. Low Apgar scores
5. Respiratory distress syndrome
6. Hypocalcemia
7. Hyperphosphatemia
8. Hypercalciuria
9. Hypomagnesemia
10. Hypoparathyroidism
11. Vitamin D deficiency
12. Chronic renal failure
13. Genetic mutations in the ENPP1 gene

At this time, there is no known cure for Generalized Arterial Calcification of Infancy (GACI). Treatment focuses on managing symptoms and preventing complications. Medications may be prescribed to help reduce inflammation, improve blood flow, and reduce calcium deposits. In some cases, surgery may be necessary to remove calcium deposits or to repair damaged arteries.