Fish-eye disease is a rare genetic disorder caused by a deficiency of the enzyme galactosylceramidase. It is characterized by the accumulation of a fatty substance called galactosylceramide in the eyes, which causes the eyes to appear to bulge outwards, giving them a fish-like appearance. Other symptoms include mental retardation, seizures, and vision problems.

The symptoms of Fish-eye disease include:

-Corneal clouding
-Decreased vision
-Corneal opacities
-Corneal edema
-Corneal thinning
-Corneal vascularization
-Corneal ulceration
-Corneal neovascularization
-Corneal scarring
-Corneal perforation
-Corneal ectasia
-Corneal dystrophy
-Corneal deposits
-Corneal degeneration
-Corneal ectropion
-Corneal ulceration with perforation

Fish-eye disease is caused by a deficiency of the essential fatty acid, omega-3. This fatty acid is found in certain types of fish, such as salmon, mackerel, herring, and sardines. It is also found in some plant sources, such as flaxseed, chia seeds, and walnuts. A lack of omega-3 in the diet can lead to a deficiency of this essential fatty acid, which can cause the symptoms of Fish-eye disease.

Fish-eye disease is a rare genetic disorder caused by a mutation in the gene that encodes the enzyme lysosomal acid lipase (LAL). Treatment for Fish-eye disease is focused on managing the symptoms and complications of the disorder. This may include dietary changes, enzyme replacement therapy, cholesterol-lowering medications, and lifestyle modifications. In some cases, liver transplantation may be recommended.

The primary risk factor for Fish-eye disease is a genetic mutation in the CEP290 gene. Other risk factors include a family history of the disease, being of Ashkenazi Jewish descent, and having a consanguineous (related) parent.

There is no known cure for Fish-eye disease, but there are medications that can help manage the symptoms. These medications include corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs), and immunosuppressants. Additionally, lifestyle modifications such as avoiding activities that may worsen the condition, eating a healthy diet, and getting regular exercise can help manage the symptoms.