Fetal Retinoid Syndrome is a rare congenital disorder caused by exposure to retinoids (vitamin A derivatives) during pregnancy. It is characterized by a variety of physical and mental abnormalities, including craniofacial malformations, skeletal malformations, and intellectual disability. It can also cause vision and hearing problems.

The symptoms of Fetal Retinoid Syndrome vary depending on the severity of the condition, but may include:
* Abnormal facial features, including a flat midface, small eyes, and a small jaw
* Cleft lip and/or palate
* Heart defects
* Abnormalities of the hands and feet, including webbed fingers and toes
* Intellectual disability
* Hearing loss
* Vision problems, including blindness
* Kidney and/or urinary tract abnormalities
* Skeletal abnormalities
* Seizures
* Growth delays

Fetal Retinoid Syndrome is caused by a mother taking high doses of vitamin A or retinoid medications during pregnancy. These medications are used to treat severe acne, psoriasis, and other skin conditions. The high doses of vitamin A can cause birth defects in the baby, including Fetal Retinoid Syndrome.

There is no cure for Fetal Retinoid Syndrome, but there are treatments available to help manage the symptoms. These treatments may include physical therapy, occupational therapy, speech therapy, and medications to help with muscle spasms, seizures, and other symptoms. Surgery may also be recommended to correct physical deformities. Additionally, genetic counseling may be recommended to help families understand the condition and its implications.

The primary risk factor for Fetal Retinoid Syndrome is maternal use of isotretinoin (Accutane) during pregnancy. Isotretinoin is a medication used to treat severe acne, and is known to cause birth defects if taken during pregnancy. Other risk factors include a family history of Fetal Retinoid Syndrome, maternal exposure to high doses of vitamin A, and maternal use of other medications that can cause birth defects.

At this time, there is no cure for Fetal Retinoid Syndrome. However, there are medications that can help manage the symptoms. These medications include anticonvulsants, muscle relaxants, and medications to help with vision and hearing. Additionally, physical and occupational therapy can help with motor skills and coordination.