Familial steroid-resistant nephrotic syndrome with sensorineural deafness is a rare genetic disorder characterized by the inability of the kidneys to respond to steroid treatment for nephrotic syndrome, a condition in which the kidneys are unable to properly filter waste from the blood, and sensorineural deafness, a type of hearing loss caused by damage to the inner ear or the nerve pathways from the inner ear to the brain. This disorder is caused by mutations in the NPHS1 gene, which is responsible for producing a protein that helps maintain the structure of the kidney's filtering units.

The symptoms of Familial steroid-resistant nephrotic syndrome with sensorineural deafness include:

- Proteinuria (excess protein in the urine)
- Edema (swelling)
- Hypertension (high blood pressure)
- Hyperlipidemia (high levels of lipids in the blood)
- Hypoalbuminemia (low levels of albumin in the blood)
- Sensorineural deafness (Hearing loss due to damage to the inner ear or auditory nerve)
- Renal insufficiency (decreased kidney function)
- Urinary tract infections
- Growth retardation
- Developmental delay
- Anemia (low red blood cell count)
- Fatigue
- Poor appetite
- Weight loss

Familial steroid-resistant nephrotic syndrome with sensorineural deafness is a rare genetic disorder caused by mutations in the NPHS1, NPHS2, or WT1 genes. Mutations in these genes can lead to abnormal development of the kidneys and inner ear, resulting in nephrotic syndrome and sensorineural deafness.

1. Corticosteroid therapy: Corticosteroids are the mainstay of treatment for Familial steroid-resistant nephrotic syndrome with sensorineural deafness. These medications help reduce inflammation and proteinuria, and can help slow the progression of the disease.

2. Immunosuppressive therapy: Immunosuppressive medications such as cyclosporine, tacrolimus, and mycophenolate mofetil can be used to help reduce inflammation and proteinuria.

3. ACE inhibitors and ARBs: These medications can help reduce proteinuria and slow the progression of the disease.

4. Diuretics: Diuretics can help reduce fluid retention and edema.

5. Hearing aids: Hearing aids can help improve hearing in those with sensorineural deafness.

6. Kid

1. Family history of the condition
2. Male gender
3. Mutations in the NPHS1, NPHS2, or LAMB2 genes
4. Exposure to certain medications or toxins
5. Premature birth
6. Low birth weight
7. Infections
8. Exposure to certain environmental factors

There is no cure for Familial steroid-resistant nephrotic syndrome with sensorineural deafness. However, medications can be used to manage the symptoms. These include diuretics to reduce fluid retention, ACE inhibitors to reduce blood pressure, and immunosuppressants to reduce inflammation. Additionally, hearing aids may be used to help with hearing loss.