About Familial partial lipodystrophy, Dunnigan type

What is Familial partial lipodystrophy, Dunnigan type?

Familial partial lipodystrophy, Dunnigan type (FPLD2) is a rare genetic disorder characterized by a loss of fat tissue from the arms, legs, and face. It is caused by mutations in the LMNA gene, which is responsible for producing the lamin A/C protein. Symptoms of FPLD2 include insulin resistance, diabetes, fatty liver, and high cholesterol. People with FPLD2 may also experience muscle weakness, joint pain, and skin changes. Treatment typically involves lifestyle modifications, such as diet and exercise, as well as medications to control blood sugar and cholesterol levels.

What are the symptoms of Familial partial lipodystrophy, Dunnigan type?

The symptoms of Familial partial lipodystrophy, Dunnigan type (FPLD2) include:

-Loss of fat from the arms, legs, and buttocks
-Accumulation of fat in the abdomen, neck, and face
-Insulin resistance
-High levels of triglycerides and cholesterol
-Enlarged liver
-High blood pressure
-Enlarged heart
-Kidney problems
-Growth retardation
-Delayed puberty
-Infertility
-Skin changes, such as thickening of the skin on the back of the neck and arms

What are the causes of Familial partial lipodystrophy, Dunnigan type?

Familial partial lipodystrophy, Dunnigan type is caused by mutations in the LMNA gene. This gene provides instructions for making a protein called lamin A, which is involved in maintaining the structure of the nucleus, the compartment of the cell that contains the genetic material. Mutations in the LMNA gene lead to the production of an abnormal form of lamin A, which disrupts the structure of the nucleus and affects the normal function of cells.

What are the treatments for Familial partial lipodystrophy, Dunnigan type?

The primary treatment for Familial partial lipodystrophy, Dunnigan type is lifestyle modification. This includes following a healthy diet, exercising regularly, and managing stress. Additionally, medications such as insulin sensitizers, growth hormone, and thiazolidinediones may be prescribed to help manage the symptoms. In some cases, surgery may be recommended to remove excess fat from certain areas of the body.

What are the risk factors for Familial partial lipodystrophy, Dunnigan type?

1. Genetic mutation: Familial partial lipodystrophy, Dunnigan type is caused by a mutation in the LMNA gene.

2. Family history: Having a family history of the condition increases the risk of developing Familial partial lipodystrophy, Dunnigan type.

3. Age: The condition is more common in adults, although it can occur at any age.

4. Gender: Women are more likely to be affected than men.

Is there a cure/medications for Familial partial lipodystrophy, Dunnigan type?

There is no cure for Familial partial lipodystrophy, Dunnigan type. However, medications such as insulin sensitizers, growth hormone, and thiazolidinediones may be used to help manage the symptoms. Additionally, lifestyle modifications such as diet and exercise may be beneficial.