Familial multiple trichoepithelioma (FMT) is a rare inherited skin disorder characterized by the development of multiple benign tumors (trichoepitheliomas) on the face, scalp, and neck. These tumors are usually small, firm, and dome-shaped, and may be skin-colored, pink, or red. They may be present at birth or develop in early childhood. FMT is caused by a mutation in the gene CYLD, which is responsible for regulating cell growth and division. Treatment typically involves surgical removal of the tumors.

The most common symptom of familial multiple trichoepithelioma is multiple small, firm, flesh-colored bumps on the face, usually around the eyes, nose, and cheeks. These bumps may be dome-shaped or flat-topped and may be itchy or tender. Other symptoms may include:

• Skin discoloration

• Thickening of the skin

• Scarring

• Cysts

• Pitted or ridged nails

• Hair loss

• Abnormal hair growth

• Eye Irritation or dryness

Familial multiple trichoepithelioma is an inherited condition caused by mutations in the gene CYLD. This gene is responsible for controlling the growth of certain cells in the skin. Mutations in this gene can lead to the development of multiple trichoepitheliomas, which are benign tumors that form on the skin.

The main treatment for familial multiple trichoepithelioma is surgical excision. This involves removing the affected areas of skin with a scalpel or laser. Other treatments may include topical medications, such as retinoids or imiquimod, to reduce the size of the lesions. In some cases, radiation therapy may be used to reduce the size of the lesions.

1. Family history of the condition
2. Inherited genetic mutations in the CYLD gene
3. Female gender
4. Fair skin
5. Exposure to ultraviolet radiation

At this time, there is no known cure for familial multiple trichoepithelioma. However, there are medications that can be used to help manage the symptoms. These include topical retinoids, topical corticosteroids, and oral isotretinoin. Additionally, laser therapy and cryotherapy may be used to reduce the size of the lesions.